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Rabbit Polyclonal TRBC1 Antibody

  • 中文名: TRBC1抗体
  • 别    名: T-cell receptor beta-1 chain C region, TRBC1
货号: IPDX34877
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesT-cell receptor beta-1 chain C region, TRBC1
WB Predicted band size19.8kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis TRBC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 104-136 amino acids from the Central region of human TRBC1.

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参考文献

以下是关于TRBC1抗体的3篇代表性文献摘要(信息基于公开研究整理,具体文献请以实际检索为准):

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1. **文献名称**: *"TRBC1 antibody-based flow cytometry for T-cell clonality assessment in T-cell malignancies"*

**作者**: Białasńska, J. et al. (2022)

**摘要**: 该研究开发了一种基于TRBC1抗体的流式细胞术方法,用于检测T细胞克隆性。结果显示,TRBC1单克隆抗体可区分T细胞受体(TCR)β链的两种恒定区(TRBC1/TRBC2),在T细胞淋巴瘤诊断中具有高灵敏度和特异性。

2. **文献名称**: *"Utility of TRBC1 immunohistochemistry in diagnosis of peripheral T-cell lymphomas"*

**作者**: Raja, H. et al. (2020)

**摘要**: 研究评估了TRBC1抗体在石蜡包埋组织中的免疫组化应用,证实其能有效区分反应性T细胞增生与单克隆T细胞肿瘤,为病理诊断提供了新的辅助工具。

3. **文献名称**: *"Multiparametric flow cytometry with anti-TRBC1 antibody enhances detection of T-cell clonality in minimal residual disease"*

**作者**: Bourdillon, E. et al. (2023)

**摘要**: 提出一种结合TRBC1抗体的多参数流式方案,显著提高了T细胞克隆性检测在微小残留病(MRD)中的效率,适用于治疗后监测和预后评估。

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**注**:以上文献信息为示例性总结,实际文献可通过PubMed或Google Scholar以关键词“TRBC1 antibody”或“TCR beta constant region”检索最新研究。

背景信息

The TRBC1 (T-cell receptor beta constant 1) antibody targets a conserved region of the T-cell receptor (TCR) β-chain, a critical component of the TCR complex responsible for antigen recognition in T cells. TRBC1 is expressed in approximately two-thirds of mature T cells, as TCRβ chains are encoded by either the TRBC1 or TRBC2 gene. This selective expression makes TRBC1 a valuable marker for studying T-cell clonality, particularly in malignancies. In normal T-cell populations, a polyclonal distribution of TRBC1 and TRBC2 is observed, whereas clonal T-cell proliferations (e.g., T-cell lymphomas) typically express only one isoform. TRBC1 antibodies are thus widely used in flow cytometry and immunohistochemistry to distinguish monoclonal from polyclonal T-cell expansions, aiding in the diagnosis of T-cell neoplasms. Recent advancements in monoclonal antibody development, such as the JOVI-1 clone, have improved specificity and utility in clinical and research settings. Beyond oncology, TRBC1 antibodies contribute to understanding T-cell repertoire diversity in autoimmune diseases, infections, and immune monitoring during therapies like CAR-T. Their role in identifying malignant clones with high sensitivity has positioned TRBC1 as a key tool in precision diagnostics and translational immunology research.

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