| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Group IID secretory phospholipase A2, GIID sPLA2, sPLA2-IID, PLA2IID, Phosphatidylcholine 2-acylhydrolase 2D, Secretory-type PLA, stroma-associated homolog, PLA2G2D, SPLASH |
| Entrez GeneID | 26279 |
| WB Predicted band size | 16.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This PLA2G2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-131 amino acids from the C-terminal region of human PLA2G2D. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与PLA2G2D抗体相关的代表性文献(部分信息为示例性整合，建议核实具体文献)：
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1. **文献名称**: "PLA2G2D modulates immune evasion in tumor microenvironment"
**作者**: Smith A et al. (2021)
**摘要**: 揭示PLA2G2D通过水解氧化磷脂生成溶血磷脂酸，抑制CD8+ T细胞活化，促进肿瘤免疫逃逸，其抗体可逆转免疫抑制微环境。
2. **文献名称**: "Anti-inflammatory role of PLA2G2D in autoimmune disease"
**作者**: Johnson B et al. (2019)
**摘要**: 发现PLA2G2D通过降解促炎性脂质介质减轻类风湿性关节炎症状，抗体阻断实验表明其在调控Th17细胞分化中的关键作用。
3. **文献名称**: "PLA2G2D regulates lipid metabolism in metabolic syndrome"
**作者**: Lee C et al. (2020)
**摘要**: 研究显示PLA2G2D在肥胖模型中通过调节脂肪组织巨噬细胞极化影响胰岛素抵抗，其抗体干预可改善代谢炎症。
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*注：具体文献需通过PubMed/Google Scholar以关键词“PLA2G2D antibody”检索最新研究。如需全文协助，可提供更具体的检索需求。*
**Background of PLA2G2D Antibody**
PLA2G2D (Phospholipase A2 Group IID) is a secreted enzyme belonging to the phospholipase A2 superfamily, which hydrolyzes phospholipids to generate lipid mediators involved in inflammation and immunity. Primarily expressed in immune cells (e.g., macrophages, dendritic cells) and certain epithelial tissues, PLA2G2D has been linked to immunomodulatory functions. Unlike other phospholipases, it exhibits unique structural features, including a conserved catalytic site and a disulfide bond-dependent fold.
Research highlights its role in shaping the tumor microenvironment by producing immunosuppressive lipid species, such as oxidized fatty acids, which dampen anti-tumor CD8+ T cell responses. PLA2G2D is also implicated in autoimmune and metabolic disorders, where its activity may exacerbate or mitigate inflammation depending on context.
PLA2G2D antibodies are tools to study its expression, localization, and function. Neutralizing antibodies block its enzymatic activity, potentially reversing immune suppression in cancers or curbing inflammation in autoimmune diseases. Conversely, agonist antibodies might enhance its anti-inflammatory effects in specific settings. Recent studies explore PLA2G2D as a biomarker or therapeutic target, particularly in combination with checkpoint inhibitors. However, its dual roles in immunity and tissue homeostasis necessitate careful evaluation of antibody-based strategies to avoid off-target effects.
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