| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | La-related protein 6, Acheron, Achn, La ribonucleoprotein domain family member 6, LARP6 |
| Entrez GeneID | 55323 |
| WB Predicted band size | 54.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This LARP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-35 amino acids from the N-terminal region of human LARP6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LARP6 (N-term)抗体的3篇参考文献及其摘要概括：
1. **文献名称**: *LARP6 binds to collagen mRNAs through its N-terminal domain to control translation specificity*
**作者**: Cai et al.
**摘要**: 该研究利用N端特异性抗体证实LARP6通过其N端结构域结合胶原mRNA的5'UTR，调控其翻译及内质网定位，揭示其在胶原合成中的关键作用。
2. **文献名称**: *Role of LARP6 in fibrosis: insights from antibody-mediated functional inhibition*
**作者**: Stefanovic et al.
**摘要**: 通过N端抗体阻断LARP6功能，发现其缺失导致胶原mRNA稳定性下降，抑制成纤维细胞中胶原蛋白分泌，表明LARP6是纤维化治疗的潜在靶点。
3. **文献名称**: *Characterization of LARP6 protein complexes by immunoprecipitation using a novel N-terminal epitope tag antibody*
**作者**: Smith et al.
**摘要**: 开发了一种针对LARP6 N端表位的抗体，通过免疫共沉淀和质谱分析，鉴定了LARP6与RNA解旋酶及翻译因子的相互作用网络，解析其分子机制。
注：以上文献为示例，实际引用需根据具体研究补充完整信息。如需准确文献，建议通过PubMed/Google Scholar检索关键词“LARP6 antibody N-terminal”或联系相关领域数据库。
The LARP6 (N-term) antibody is a reagent designed to detect the N-terminal region of La-related protein 6 (LARP6), a member of the La-related protein family involved in RNA metabolism. LARP6 specifically binds to the 5′ stem-loop structure of collagen mRNAs, particularly type I collagen, and regulates their stability and translation in the endoplasmic reticulum. This interaction is critical for maintaining extracellular matrix (ECM) homeostasis, as collagen is a key structural protein in connective tissues.
The antibody is widely used in research to study LARP6's role in collagen biosynthesis, tissue fibrosis, and diseases like liver fibrosis, pulmonary fibrosis, and cancer metastasis. By targeting the N-terminal domain, it helps identify LARP6 expression levels, subcellular localization (primarily cytoplasmic), and interactions with RNA or protein partners via techniques like Western blotting, immunoprecipitation, and immunofluorescence.
Studies using this antibody have highlighted LARP6's pathological significance, including its dysregulation in fibrotic disorders and tumor microenvironments. Its specificity for the N-terminal epitope ensures minimal cross-reactivity with other LARP family members, making it a valuable tool for dissecting post-transcriptional mechanisms of ECM remodeling and developing therapeutic strategies targeting fibrosis or collagen-related pathologies.
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