Rabbit Polyclonal ORMDL3 Antibody

ORMDL3. a member of the ORMDL family (ORMDL1. ORMDL2. ORMDL3), is an endoplasmic reticulum (ER)-resident transmembrane protein implicated in sphingolipid metabolism regulation and the unfolded protein response (UPR). Initially linked to asthma susceptibility through genome-wide association studies (GWAS), ORMDL3 has since been associated with inflammatory diseases like inflammatory bowel disease (IBD) and type 1 diabetes. It modulates serine palmitoyltransferase (SPT), the rate-limiting enzyme in sphingolipid biosynthesis, influencing ceramide levels and ER stress signaling. ORMDL3 antibodies are essential tools for detecting ORMDL3 expression in research, enabling studies on its role in cellular stress responses, immune regulation, and disease mechanisms. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and flow cytometry to explore tissue-specific expression patterns, subcellular localization, and interactions with other UPR components. Recent studies also highlight ORMDL3's involvement in autophagy, apoptosis, and cytokine production, underscoring its therapeutic potential. Commercial ORMDL3 antibodies are typically raised against specific epitopes (e.g., human ORMDL3 N-terminal peptides) and validated for specificity across human and murine models. Ongoing research aims to clarify its dual roles in lipid homeostasis and inflammation, with antibodies serving as critical reagents for mechanistic and translational investigations.