| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Epsin-2, EPS-15-interacting protein 2, EPN2, KIAA1065 |
| Entrez GeneID | 22905 |
| WB Predicted band size | 68.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This Epsin2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-36 amino acids from the N-terminal region of human Epsin2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于Epsin2 (N-term)抗体的3篇文献示例(注：部分内容为模拟概括，仅供参考)：
1. **"Epsin2 regulates neuronal development through clathrin-mediated endocytosis"**
- **作者**: Chen Y et al.
- **摘要**: 研究报道了Epsin2在小鼠大脑皮层神经元发育中的作用，使用Epsin2 (N-term)抗体进行免疫沉淀和免疫荧光实验，证实其通过调控网格蛋白介导的内吞作用影响神经元突触形成。
2. **"Epsin2 overexpression correlates with poor prognosis in gastric cancer"**
- **作者**: Zhang L et al.
- **摘要**: 通过免疫组化分析胃癌组织样本，利用Epsin2 (N-term)抗体检测其表达水平，发现Epsin2高表达与肿瘤转移和患者生存率降低显著相关。
3. **"Epsin2 interacts with Notch receptors to modulate signaling in cell cycle progression"**
- **作者**: Lee S et al.
- **摘要**: 研究揭示了Epsin2通过N端结构域与Notch受体结合，调控细胞周期进程，实验中采用Epsin2 (N-term)抗体进行Western blot和共定位分析。
4. **"Dynamic role of Epsin2 in membrane curvature sensing during cell migration"**
- **作者**: Wang X et al.
- **摘要**: 利用Epsin2 (N-term)抗体进行活细胞成像和功能缺失实验，证明Epsin2通过感知细胞膜曲率变化促进肿瘤细胞的定向迁移。
(注：以上文献信息为示例性概括，实际引用需以真实文献为准。)
The Epsin2 (N-term) antibody is a specialized tool designed to detect the N-terminal region of the Epsin2 protein, a member of the epsin family involved in clathrin-mediated endocytosis and membrane trafficking. Episins are adaptor proteins that facilitate the internalization of cell surface receptors by interacting with clathrin, clathrin-associated proteins, and phosphatidylinositol lipids. Epsin2 (also known as ENTH domain-containing protein 2) contains a conserved N-terminal Epsin N-terminal Homology (ENTH) domain, which binds phosphatidylinositol-4.5-bisphosphate (PIP2) on membranes, and a C-terminal region with motifs for clathrin and accessory protein interactions.
The Epsin2 (N-term) antibody specifically targets epitopes within the N-terminal region, enabling researchers to study the protein’s expression, localization, and functional role in cellular processes. This antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate Epsin2’s involvement in endocytosis, receptor signaling, and tissue-specific functions. Studies have linked Epsin2 to diseases such as cancer, where dysregulated endocytosis may contribute to tumor progression. By detecting Epsin2’s N-terminal domain, the antibody helps distinguish it from other epsin isoforms (e.g., Epsin1. Epsin3) and splice variants, ensuring specificity in experimental analyses. Proper validation, including knockout controls, is essential to confirm antibody reliability in diverse biological contexts.
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