| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Xin actin-binding repeat-containing protein 1, Cardiomyopathy-associated protein 1, XIRP1, CMYA1, XIN |
| Entrez GeneID | 165904 |
| WB Predicted band size | 198.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This XIRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1338-1367 amino acids from the C-terminal region of human XIRP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于XIRP1抗体的3篇参考文献，按简单格式整理：
1. **文献名称**: "Xin Proteins and Cardiac Development"
**作者**: Wang et al. (2015)
**摘要**: 研究探讨了XIRP1(Xin)蛋白在小鼠心脏发育中的作用，利用特异性抗体进行免疫荧光和Western blot分析，发现XIRP1在心肌细胞黏着连接处富集，对心脏形态发生至关重要。
2. **文献名称**: "XIRP1 Regulates Sarcomere Assembly in Cardiomyocytes"
**作者**: Li et al. (2018)
**摘要**: 通过XIRP1抗体进行共聚焦成像和免疫沉淀实验，揭示了XIRP1与α-actinin相互作用，调控肌节组装，并发现其突变与心肌病相关。
3. **文献名称**: "Antibody-Based Detection of Xin Protein in Human Heart Tissue"
**作者**: Garcia et al. (2020)
**摘要**: 开发了一种高特异性人源XIRP1单克隆抗体，应用于组织芯片分析，证明XIRP1在心力衰竭患者心肌中表达显著下调，提示其作为潜在生物标志物的价值。
注：上述文献信息为示例性质，实际引用时请核对真实文献来源及细节。
The XIRP1 (Xin Actin Binding Repeat Containing Protein 1) antibody is a tool used to study the function and expression of XIRP1. a protein predominantly expressed in cardiac and skeletal muscle tissues. XIRP1. also known as Xin, plays a critical role in maintaining sarcomeric integrity and regulating actin cytoskeleton dynamics during muscle development and repair. It localizes to intercalated discs in cardiomyocytes, where it interacts with α-catenin and β-catenin to stabilize cell-cell adhesion complexes. XIRP1 is implicated in cardiac morphogenesis, electrical conduction, and response to mechanical stress. Dysregulation of XIRP1 has been linked to arrhythmias, cardiomyopathy, and muscular dystrophy.
The XIRP1 antibody is widely used in research to detect protein expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence. It helps investigate XIRP1’s role in cardiac regeneration, disease mechanisms, and cytoskeletal organization. Studies using knockout models show that XIRP1 deficiency leads to structural defects in cardiac muscle and impaired stress response. Commercially available XIRP1 antibodies are typically validated for specificity against human, mouse, or rat samples. Recent research explores its potential as a biomarker for cardiac injury or as a therapeutic target in muscle-related disorders. Proper validation of antibody specificity, including knockout controls, is essential due to possible cross-reactivity with homologous proteins like XIRP2.
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