| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | WD repeat-containing protein 70, WDR70 |
| Entrez GeneID | 55100 |
| WB Predicted band size | 73.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This WDR70 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-604 amino acids from the C-terminal region of human WDR70. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于WDR70抗体的3篇参考文献及其摘要概括(注：文献信息为模拟示例，实际研究中需核实真实文献)：
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1. **文献名称**: *WDR70 interacts with the histone methyltransferase complex to regulate ciliogenesis*
**作者**: Smith J, et al. (2021)
**摘要**: 本研究利用WDR70特异性抗体，通过免疫共沉淀和质谱分析发现WDR70与组蛋白甲基转移酶复合物(如SETD2)存在相互作用。实验表明，WDR70在纤毛形成中发挥关键作用，其缺失导致细胞纤毛结构异常。抗体应用包括Western blot和免疫荧光定位WDR70在纤毛基部的表达。
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2. **文献名称**: *WDR70 is a novel DNA repair factor involved in homologous recombination*
**作者**: Lee H, et al. (2019)
**摘要**: 研究通过CRISPR筛选发现WDR70参与同源重组修复(HR)。使用WDR70抗体进行染色质免疫沉淀(ChIP)实验，证实其在DNA损伤位点的富集。此外，抗体介导的蛋白质敲降实验显示WDR70缺失导致HR效率下降，提示其维持基因组稳定的功能。
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3. **文献名称**: *Dysregulation of WDR70 in hepatocellular carcinoma correlates with poor prognosis*
**作者**: Zhang R, et al. (2020)
**摘要**: 该研究通过WDR70抗体对肝癌组织进行免疫组化分析，发现WDR70蛋白表达水平与患者生存率显著相关。体外实验进一步表明，WDR70通过调控细胞周期相关蛋白(如Cyclin D1)抑制肿瘤增殖，为潜在治疗靶点提供依据。
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**备注**：以上文献为模拟生成，实际研究中建议通过PubMed或Google Scholar以“WDR70 antibody”为关键词检索，并筛选涉及抗体应用的实验论文(如功能研究、蛋白质互作或疾病机制)。
WDR70 (WD Repeat Domain 70) is a protein encoded by the *WDR70* gene in humans, belonging to the WD40 repeat protein family. These proteins are characterized by conserved WD40 domains that facilitate protein-protein interactions, often acting as scaffolds for multiprotein complexes. WDR70 is implicated in diverse cellular processes, including ciliogenesis, cell cycle regulation, and autophagy. Studies suggest its role in maintaining primary cilia, sensory organelles critical for signaling pathways (e.g., Hedgehog signaling), and its dysfunction has been linked to ciliopathies and developmental disorders.
WDR70 antibodies are essential tools for detecting and characterizing the protein in research. They are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study WDR70 expression, localization, and interactions. Polyclonal and monoclonal antibodies raised in hosts such as rabbits or mice are commercially available, often validated for reactivity in humans, mice, and other model organisms.
Research using WDR70 antibodies has revealed its nuclear-cytoplasmic shuttling behavior and dynamic expression during cell cycle progression. Abnormal WDR70 expression has been observed in certain cancers, suggesting potential roles in tumorigenesis. Additionally, WDR70’s interaction with TAF proteins highlights its possible involvement in transcriptional regulation. These findings underscore the antibody’s utility in elucidating WDR70’s molecular mechanisms and its relevance to human health, particularly in cilia-related pathologies and cancer biology.
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