| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Nuclear receptor subfamily 2 group C member 2, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, Testicular receptor 4, NR2C2, TAK1, TR4 |
| Entrez GeneID | 7182 |
| WB Predicted band size | 65.4kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between amino acids from human. |
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以下是关于NR2C2抗体的3篇参考文献及其摘要概括：
1. **《NR2C2在肝癌中的转录调控作用》**
- 作者：Liu X, et al.
- 摘要：研究通过Western blot和免疫组化技术，利用NR2C2抗体分析其在肝癌组织中的表达上调，发现NR2C2通过激活Wnt/β-catenin通路促进肿瘤增殖和转移。
2. **《NR2C2调控脂肪生成的关键机制》**
- 作者：Zhang Y, et al.
- 摘要：该研究使用NR2C2抗体进行ChIP-seq和染色质免疫沉淀，揭示NR2C2直接结合脂肪生成相关基因启动子区域，调控小鼠脂肪细胞分化及代谢平衡。
3. **《NR2C2基因敲除小鼠模型的代谢表型分析》**
- 作者：Wang H, et al.
- 摘要：通过NR2C2抗体检测敲除小鼠多个组织的蛋白表达，发现其缺失导致糖代谢异常和胰岛素抵抗，表明NR2C2在代谢综合征中的关键作用。
(注：以上文献信息为示例性质，实际引用需根据具体论文调整。)
The nuclear receptor subfamily 2 group C member 2 (NR2C2), also known as testicular receptor 4 (TR4), is a transcription factor belonging to the nuclear receptor superfamily. It contains a conserved DNA-binding domain and a ligand-binding domain, enabling it to regulate gene expression by binding to specific DNA response elements. NR2C2 is involved in diverse physiological processes, including metabolic regulation, cell differentiation, embryonic development, and circadian rhythm control. Studies link it to lipid and glucose homeostasis, with roles in liver, adipose tissue, and central nervous system function. It also participates in reproductive system development and neuronal differentiation.
Dysregulation of NR2C2 has been associated with metabolic disorders (e.g., diabetes, obesity), cancers (prostate, liver, and breast), and neurodegenerative diseases. Its dual role as oncogene or tumor suppressor appears context-dependent, influencing cell proliferation and apoptosis pathways.
NR2C2 antibodies are essential tools for investigating its expression patterns, subcellular localization, and molecular interactions. Widely used in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP), these antibodies help identify tissue-specific expression profiles and disease correlations. Commercial antibodies are typically raised against specific epitopes in the N-terminal or DNA-binding domains. Validation through knockout controls or siRNA experiments is critical due to potential cross-reactivity with related nuclear receptors. Recent research leverages NR2C2 antibodies to explore its therapeutic potential in metabolic syndrome and cancer treatment strategies.
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