Rabbit Polyclonal SUMO4(M55Wildtype) Antibody

The SUMO4 (M55 Wild type) antibody is a specialized tool used to detect the small ubiquitin-like modifier 4 (SUMO4) protein in its wild-type form, specifically targeting the methionine residue at position 55. SUMO4 belongs to the SUMO protein family (SUMO1-4), which post-translationally modifies target proteins through a process called SUMOylation, regulating their activity, localization, and stability. Unlike other SUMO paralogs, SUMO4 is predominantly expressed in immune tissues and has been linked to inflammatory and autoimmune diseases. A single-nucleotide polymorphism (SNP) substituting methionine (M55) with valine (V55) in SUMO4 is associated with altered NF-κB signaling and increased susceptibility to conditions like type 1 diabetes and lupus. The M55 Wild type antibody distinguishes the wild-type SUMO4 from the M55V variant, enabling researchers to study the functional differences between these forms. It is widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate SUMO4's role in cellular stress responses, immune regulation, and disease mechanisms. This antibody is particularly valuable for exploring how wild-type SUMO4 modulates inflammatory pathways and interacts with substrates compared to its polymorphic counterpart, offering insights into therapeutic targeting of SUMOylation-related disorders.