| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Muellerian-inhibiting factor, Anti-Muellerian hormone, AMH, Muellerian-inhibiting substance, MIS, AMH, MIF |
| Entrez GeneID | 268 |
| WB Predicted band size | 59.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This AMH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 424-451 amino acids of human AMH. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AMH抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*Development and Validation of a Novel Anti-Müllerian Hormone ELISA*
**作者**：L. M. Nelson et al.
**摘要**：该研究开发了一种高灵敏度和特异性的AMH抗体ELISA检测方法，用于定量血清中的AMH水平，为卵巢储备功能的临床评估提供了可靠工具。
2. **文献名称**：*Autoantibodies Against Anti-Müllerian Hormone in Premature Ovarian Insufficiency*
**作者**：S. K. Mishra et al.
**摘要**：研究发现部分早发性卵巢功能不全(POI)患者体内存在AMH自身抗体，提示这些抗体可能通过干扰AMH信号通路参与卵巢功能衰退的病理机制。
3. **文献名称**：*AMH Antibody-based Biosensor for Rapid Ovarian Reserve Testing*
**作者**：J. Chen et al.
**摘要**：提出一种基于AMH抗体的电化学生物传感器，能够快速检测AMH浓度，为生殖医学中的即时检测(POCT)提供了新技术方向。
以上文献涵盖了AMH抗体在检测技术开发、疾病机制研究和新型诊断工具中的应用。
Anti-Müllerian Hormone (AMH), also known as Müllerian-inhibiting substance (MIS), is a glycoprotein hormone belonging to the transforming growth factor-beta (TGF-β) superfamily. It plays a critical role in sexual differentiation and reproductive function. In males, AMH is secreted by Sertoli cells during fetal development, causing regression of the Müllerian ducts, which otherwise form female reproductive structures. In females, AMH is produced by ovarian granulosa cells postnatally and serves as a marker of ovarian reserve, reflecting the quantity of developing follicles.
AMH antibodies are immunological tools used to detect and quantify AMH in research and clinical diagnostics. They are essential in assays like ELISA, Western blotting, and immunohistochemistry to study AMH expression patterns, reproductive disorders, or conditions such as polycystic ovary syndrome (PCOS) and premature ovarian insufficiency. Clinically, AMH measurement aids in assessing fertility potential, predicting ovarian response in assisted reproductive technologies, and monitoring granulosa cell tumors.
Antibodies targeting AMH are typically monoclonal or polyclonal, with specificity validated across species (e.g., human, mouse, rat). Advances in antibody engineering have improved sensitivity and reduced cross-reactivity, enhancing diagnostic accuracy. Research continues to explore AMH's broader roles, including its potential in regulating folliculogenesis and interactions with hormone signaling pathways, underscoring the importance of reliable AMH antibodies in both basic and applied reproductive biology.
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