Rabbit Polyclonal INPP5B Antibody

The INPP5B (Inositol Polyphosphate-5-Phosphatase B) antibody is a key tool for studying the INPP5B protein, a member of the 5-phosphatase family that hydrolyzes phosphatidylinositol (PI) lipids, particularly PI(4.5)P2 and PI(3.4.5)P3. These lipids regulate critical cellular processes, including membrane trafficking, cytoskeletal organization, and signal transduction. INPP5B localizes to the cytoplasm and endosomal compartments, where it modulates phosphoinositide metabolism, impacting pathways like insulin signaling and vesicle transport. Dysregulation of INPP5B has been linked to metabolic disorders, neurodegenerative diseases, and cancer progression. Antibodies targeting INPP5B are typically developed in hosts such as rabbits or mice, using immunogens derived from specific protein regions (e.g., N-terminal or catalytic domains). They are validated for applications like Western blotting, immunofluorescence, and immunoprecipitation to assess protein expression, localization, and interactions. Researchers use these antibodies to explore INPP5B's role in cellular homeostasis, disease mechanisms, and its potential as a therapeutic target. Specificity is confirmed via knockout controls or siRNA knockdown. Commercial INPP5B antibodies often include detailed validation data, ensuring reproducibility in studies of phosphoinositide signaling networks.