| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Inositol monophosphatase 1, IMP 1, IMPase 1, 3.1.3.25, D-galactose 1-phosphate phosphatase, 3.1.3.94, Inositol-1(or 4)-monophosphatase 1, Lithium-sensitive myo-inositol monophosphatase A1, IMPA1, IMPA |
| Entrez GeneID | 3612 |
| WB Predicted band size | 30.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This IMPA1 antibody is generated from a mouse immunized with a recombinant protein from the human region of human IMPA1. |
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以下是关于IMPA1抗体的3篇参考文献及其摘要概述：
1. **"IMPA1 expression in bipolar disorder: A link to lithium's therapeutic mechanism"**
*作者：Smith A et al.*
摘要：研究通过Western blot和免疫组化分析IMPA1蛋白在双相情感障碍患者脑组织中的表达水平，发现锂盐治疗可上调IMPA1活性，提示其抗体在检测酶活性变化中的应用价值。
2. **"Neuronal localization and developmental regulation of IMPA1 in mouse brain"**
*作者：Chen L et al.*
摘要：利用IMPA1特异性抗体进行小鼠脑组织免疫荧光染色，揭示该酶在神经元突触中的动态分布，并发现其表达随发育阶段变化，为神经发育研究提供工具支持。
3. **"IMPA1 as a potential biomarker in glioblastoma: Antibody-based proteomic analysis"**
*作者：Kim H et al.*
摘要：通过免疫沉淀结合质谱分析，验证IMPA1抗体在胶质母细胞瘤样本中的特异性识别能力，发现肿瘤组织中IMPA1异常高表达，提示其作为生物标志物的潜力。
4. **"Antibody validation for IMPA1 knockout mouse models"**
*作者：Wang Y et al.*
摘要：系统性验证多种IMPA1抗体在基因敲除小鼠模型中的特异性，确立Western blot和免疫组化标准化流程，强调抗体选择对精准检测蛋白质缺失至关重要。
(注：以上文献信息为模拟虚构，实际研究中请通过PubMed等数据库检索真实文献。)
The IMPA1 (Inositol Monophosphatase 1) antibody is a key tool for studying the IMPA1 enzyme, which plays a critical role in the phosphatidylinositol (PI) signaling pathway. IMPA1 catalyzes the dephosphorylation of inositol monophosphate to regenerate free inositol, a precursor for phosphoinositides involved in intracellular signaling, neurotransmitter regulation, and cellular stress responses. IMPA1 is notably sensitive to lithium, a first-line treatment for bipolar disorder, as lithium inhibits IMPA1 and other enzymes in the inositol cycle, modulating signaling pathways implicated in mood regulation.
IMPA1 antibodies are widely used in neuroscience and psychiatric research to investigate IMPA1 expression, localization, and function in both normal and pathological conditions. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to quantify protein levels or visualize distribution in tissues, particularly in the brain. Studies using these antibodies have linked IMPA1 dysregulation to bipolar disorder, schizophrenia, and neurodevelopmental disorders, with some research suggesting altered IMPA1 expression may influence lithium treatment responsiveness.
Validated IMPA1 antibodies are essential for specificity, often tested in knockout models to confirm minimal cross-reactivity. Their application extends to exploring IMPA1’s role in cellular processes like apoptosis, autophagy, and neuronal plasticity, offering insights into disease mechanisms and potential therapeutic targets. As genetic variants in IMPA1 are associated with intellectual disability and neurological deficits, these antibodies also support research into rare genetic disorders, bridging molecular pathways with clinical phenotypes.
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