Rabbit Polyclonal YTHD3 Antibody

The YTHDF3 antibody is a crucial tool for studying the YTH domain-containing family protein 3 (YTHDF3), a reader of N6-methyladenosine (m6A), the most abundant internal RNA modification in eukaryotes. YTHDF3 belongs to the YTHDF subfamily, which includes YTHDF1 and YTHDF2. and plays roles in mRNA metabolism, including translation regulation, stability control, and phase separation. While YTHDF1 and YTHDF2 are well-characterized, YTHDF3’s functions remain partially understood, though it appears to cooperate with both in modulating m6A-mediated processes, such as promoting translation under specific conditions or aiding mRNA decay. The YTHDF3 antibody enables detection and localization of endogenous YTHDF3 in various experimental setups, including Western blotting, immunoprecipitation (IP), and immunofluorescence (IF). Its specificity is validated through knockout controls, ensuring reliable identification of YTHDF3 expression across tissues and cell types. Research leveraging this antibody has linked YTHDF3 to diverse physiological and pathological pathways, including cancer progression, neurodevelopment, and viral infection. For instance, YTHDF3 dysregulation correlates with tumorigenesis by affecting oncogene expression or modulating immune responses. Additionally, studies highlight its role in neuronal functions and neurodegenerative diseases. The antibody’s utility extends to exploring m6A’s dynamic regulatory network, providing insights into post-transcriptional gene regulation mechanisms. As m6A research expands, YTHDF3 antibodies remain vital for dissecting its context-dependent roles in health and disease.