| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 2H2, Hs6M1-12, Olfactory receptor 2H3, Olfactory receptor-like protein FAT11, OR2H2, FAT11, OLFR2, OR2H3 |
| Entrez GeneID | 7932 |
| WB Predicted band size | 34.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR2H2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 276-302 amino acids from the C-terminal region of human OR2H2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于OR2H2抗体的3篇参考文献(部分信息为模拟，实际文献需核实)：
1. **文献名称**: "OR2H2 as a novel biomarker in lung cancer: Expression analysis and functional implications"
**作者**: Zhang Y, et al.
**摘要**: 研究通过免疫组化分析OR2H2在肺癌组织中的表达，发现其高表达与患者预后不良相关。利用特异性抗体阻断OR2H2可抑制癌细胞迁移，提示其作为治疗靶点的潜力。
2. **文献名称**: "Characterization of a monoclonal antibody targeting the extracellular domain of OR2H2 for olfactory receptor studies"
**作者**: Smith JL, et al.
**摘要**: 开发了一种针对OR2H2胞外结构域的单克隆抗体，验证了其在流式细胞术和免疫荧光中的特异性，为嗅觉受体在非嗅觉组织中的功能研究提供了工具。
3. **文献名称**: "Structural insights into OR2H2 activation mechanism through antibody-mediated crystallization"
**作者**: Tanaka K, et al.
**摘要**: 利用OR2H2抗体辅助进行受体结晶，解析了其配体结合域的三维结构，揭示了该受体与特定气味分子相互作用的分子机制。
注：以上文献信息为示例性质，实际引用需根据具体研究通过PubMed或Web of Science等平台检索核实。
The OR2H2 antibody targets olfactory receptor family 2 subfamily H member 2 (OR2H2), a G protein-coupled receptor (GPCR) primarily associated with olfactory perception. OR2H2 is part of the large olfactory receptor family, which detects odorant molecules and mediates signal transduction in nasal olfactory neurons. While its canonical role involves odorant binding and sensory signaling, emerging studies suggest broader expression in non-olfactory tissues, including the testes, hinting at potential roles in reproductive physiology or cellular communication.
OR2H2 antibodies are essential tools for investigating the receptor’s expression patterns, subcellular localization, and functional mechanisms. These antibodies, often raised in rabbits or mice, are validated for applications like Western blotting, immunohistochemistry, and flow cytometry. Researchers utilize them to explore OR2H2’s tissue-specific roles, particularly in contexts beyond olfaction, such as its speculated involvement in sperm maturation or hormone regulation.
Recent studies also examine OR2H2’s potential links to diseases, including certain cancers, where altered expression may serve as a biomarker. Structural analyses highlight conserved motifs in OR2H2 critical for ligand interaction and GPCR signaling pathways. Overall, OR2H2 antibodies bridge molecular insights into both sensory biology and unexpected physiological roles, driving interdisciplinary research in neuroscience, reproduction, and disease mechanisms.
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