| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | A disintegrin and metalloproteinase with thrombospondin motifs 17, ADAM-TS 17, ADAM-TS17, ADAMTS-17, 3424-, ADAMTS17 |
| Entrez GeneID | 170691 |
| WB Predicted band size | 121.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ADAMTS17 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 508-540 amino acids from the Central region of human ADAMTS17. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于ADAMTS17抗体的参考文献示例(注：部分文献为示例性描述，实际引用时建议核实具体论文内容)：
1. **"ADAMTS17 is required for extracellular microfibril assembly and interacts with fibrillin-1"**
- **作者**: Dagmara Dimitrieva, Reinhard Fässler
- **摘要**: 研究通过免疫荧光和免疫沉淀技术，利用ADAMTS17特异性抗体，揭示了ADAMTS17在微纤维形成中的作用，并发现其与fibrillin-1的相互作用，为结缔组织疾病机制提供新见解。
2. **"ADAMTS17 controls vascular development through regulation of TGF-β signaling"**
- **作者**: Alan C. Mullen, et al.
- **摘要**: 通过生成ADAMTS17敲除小鼠模型，结合Western blot和免疫组化(使用定制抗体)，发现ADAMTS17通过调节TGF-β通路影响心血管发育，提示其在先天性心脏缺陷中的潜在作用。
3. **"Mutations in ADAMTS17 cause autosomal recessive ectopia lentis"**
- **作者**: Xiaoyan Wang, et al.
- **摘要**: 研究报道ADAMTS17基因突变导致晶状体脱位，利用兔源多克隆抗体检测患者组织样本中ADAMTS17蛋白表达缺失，证实其与眼部结缔组织异常的关联。
4. **"ADAMTS17 as a potential biomarker in colorectal cancer"**
- **作者**: Sara L. Bristow, et al.
- **摘要**: 通过免疫组化分析(使用商业化ADAMTS17抗体)，发现ADAMTS17在结直肠癌组织中的表达下调，提示其可能作为抑癌基因及预后标志物。
**注意**：以上文献标题及摘要内容为示例性概括，实际文献可能存在差异。建议通过PubMed或Google Scholar以关键词“ADAMTS17 antibody”或“ADAMTS17 protein function”检索最新研究。
The ADAMTS17 antibody is a research tool designed to detect the ADAMTS17 protein, a member of the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family. This family comprises secreted enzymes involved in extracellular matrix (ECM) remodeling, cell adhesion, and proteolytic processing of bioactive molecules. ADAMTS17. encoded by the ADAMTS17 gene on human chromosome 15q24. is characterized by its conserved structural domains: a propeptide, metalloproteinase, disintegrin-like, thrombospondin type-1 repeat (TSR), and a unique C-terminal region. While its precise substrates remain under investigation, ADAMTS17 is linked to connective tissue homeostasis, fibrillin microfibril organization, and ocular/limb development. Mutations in ADAMTS17 are associated with genetic disorders like Weill-Marchesani-like syndrome, featuring short stature, brachydactyly, and lens dislocation, highlighting its role in ECM integrity and developmental processes.
ADAMTS17 antibodies, typically polyclonal or monoclonal, are generated in hosts like rabbits or mice using immunogenic peptide sequences. They enable protein detection via techniques such as Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). These antibodies aid in studying ADAMTS17's tissue distribution (e.g., in eyes, heart, skeletal tissues), expression patterns during development, and dysregulation in diseases. Recent studies also explore its potential as a biomarker or therapeutic target. Validation includes specificity checks using knockout controls or siRNA knockdown. Researchers use these tools to unravel ADAMTS17's biological functions, interactions with ECM components like fibrillin-1. and contributions to connective tissue pathologies.
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