| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | S-adenosylmethionine synthase isoform type-2, AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2, Methionine adenosyltransferase II, MAT-II, MAT2A, AMS2, MATA2 |
| Entrez GeneID | 4144 |
| WB Predicted band size | 43.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This MAT2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-55 amino acids from the N-terminal region of human MAT2A. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及MAT2A (N-term)抗体的参考文献摘要简述：
1. **文献名称**：*MAT2A promotes tumor progression through regulation of mitochondrial dynamics in clear cell renal cell carcinoma*
**作者**：Zhang et al.
**摘要**：该研究使用MAT2A (N-term)抗体进行Western blot和免疫组化实验，验证MAT2A在肾透明细胞癌中的高表达，并揭示其通过调控线粒体分裂蛋白DRP1促进肿瘤进展的机制。
2. **文献名称**：*Targeting MAT2A inhibits methionine metabolism and enhances cisplatin chemosensitivity in gastric cancer*
**作者**：Liu et al.
**摘要**：研究者利用MAT2A (N-term)抗体进行免疫荧光和蛋白质印迹分析，发现抑制MAT2A可阻断甲硫氨酸代谢通路，增强胃癌细胞对顺铂的敏感性，为联合化疗提供新靶点。
3. **文献名称**：*MAT2A-mediated S-adenosylmethionine biosynthesis is essential for histone methylation in pancreatic cancer*
**作者**：Yang et al.
**摘要**：通过MAT2A (N-term)抗体的染色质免疫沉淀(ChIP)实验，证实MAT2A缺失导致胰腺癌细胞组蛋白H3K4me3修饰异常，进而抑制肿瘤增殖和转移。
注：以上文献为示例性概括，实际引用需以具体论文内容为准。建议通过PubMed或Google Scholar以“MAT2A antibody N-terminal”为关键词检索最新研究。
The MAT2A (N-term) antibody is a specific tool designed to detect the N-terminal region of methionine adenosyltransferase 2α (MAT2A), a key enzyme in methionine metabolism. MAT2A catalyzes the formation of S-adenosylmethionine (SAMe), the primary methyl donor for methylation reactions involving DNA, proteins, lipids, and other molecules. Unlike its liver-specific isoform MAT1A, MAT2A is ubiquitously expressed, particularly in proliferating tissues and cancers, where it supports elevated SAMe demands for cell growth and epigenetic regulation.
This antibody targets the N-terminal domain of MAT2A, a region critical for enzymatic activity and interaction with regulatory subunits like MAT2β. Researchers commonly use the MAT2A (N-term) antibody in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study MAT2A expression, localization, and regulation in various contexts, including cancer biology, metabolic disorders, and liver diseases. Its specificity is often validated through knockdown/knockout controls or peptide blocking assays to ensure minimal cross-reactivity with homologous proteins.
Given MAT2A's role in sustaining SAMe levels and its overexpression in certain cancers, this antibody is a valuable tool for exploring therapeutic targeting of MAT2A in oncology or understanding metabolic dysregulation linked to SAMe deficiency.
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