Rabbit Polyclonal CDH10 Antibody

The CDH10 antibody is a research tool targeting cadherin-10 (CDH10), a member of the cadherin superfamily of calcium-dependent cell adhesion proteins. Cadherins play critical roles in tissue morphogenesis, neural circuit formation, and cellular recognition. CDH10. specifically, is predominantly expressed in the brain, particularly during early neurodevelopment, and is implicated in synaptic connectivity and regional brain patterning. Studies link CDH10 to autism spectrum disorder (ASD), as genome-wide association studies (GWAS) have identified CDH10 as a susceptibility gene. Antibodies against CDH10 enable researchers to investigate its expression patterns, localization, and interactions in neural tissues, aiding in understanding its role in neurodevelopmental disorders. These antibodies are typically produced in hosts like rabbits or mice using immunogenic CDH10 peptide sequences. Applications include Western blotting, immunohistochemistry, and immunofluorescence to study protein distribution in brain regions like the prefrontal cortex, where CDH10 is highly active. Research using CDH10 antibodies has contributed to insights into altered neural adhesion mechanisms in ASD and other neuropsychiatric conditions, offering potential pathways for exploring structural and functional brain abnormalities. Its utility extends to developmental biology, cancer research (due to cadherin dysregulation in tumors), and synapse formation studies.