Rabbit Polyclonal MMRN2 Antibody

MMRN2 (Multimerin 2) is a secreted glycoprotein belonging to the multimerin family, characterized by its large, disulfide-linked polymeric structure. It is primarily expressed in vascular and lymphatic endothelial cells, where it localizes to the extracellular matrix (ECM). MMRN2 plays a role in regulating endothelial cell adhesion, migration, and vascular remodeling by interacting with ECM components and cell surface receptors, such as integrins. Its involvement in angiogenesis and vascular stability has linked it to physiological processes like tissue repair and pathological conditions, including tumor angiogenesis and cardiovascular diseases. Antibodies targeting MMRN2 are valuable tools for studying its expression, distribution, and function in vascular biology. They are used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to explore MMRN2's role in endothelial cell behavior and vascular pathologies. Recent research also investigates its potential as a biomarker or therapeutic target in cancers, leveraging its overexpression in tumor-associated vasculature. However, the functional complexity of MMRN2. including its interactions with other ECM proteins and signaling pathways, remains an active area of study.