| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ecto-NOX disulfide-thiol exchanger 2, APK1 antigen, Cytosolic ovarian carcinoma antigen 1, Tumor-associated hydroquinone oxidase, tNOX, Hydroquinone [NADH] oxidase, 1---, Protein disulfide-thiol oxidoreductase, 1---, ENOX2, COVA1 |
| Entrez GeneID | 10495 |
| WB Predicted band size | 70.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ENOX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human ENOX2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ENOX2 (N-term)抗体的虚构参考文献示例(注：内容为模拟生成，非真实文献)：
1. **文献名称**: *"Characterization of ENOX2 (N-term) Antibody in Cancer Cell Proliferation"*
**作者**: Zhang et al. (2015)
**摘要**: 研究验证了ENOX2 (N-term)抗体在识别癌细胞膜表面ENOX2蛋白的特异性，发现其表达水平与肿瘤细胞增殖和迁移能力正相关，可能作为癌症治疗的潜在靶点。
2. **文献名称**: *"Development of a Monoclonal Antibody Targeting the N-terminal Domain of ENOX2"*
**作者**: Smith et al. (2018)
**摘要**: 报道了一种新型ENOX2 (N-term)单克隆抗体的开发，通过免疫印迹和免疫组化证实其高特异性，可用于检测多种癌症组织中ENOX2的异常表达。
3. **文献名称**: *"ENOX2 as a Serum Biomarker: Validation Using N-term-specific Antibodies"*
**作者**: Brown et al. (2020)
**摘要**: 利用ENOX2 (N-term)抗体检测患者血清中的ENOX2水平，发现其与结直肠癌进展显著相关，提示其作为非侵入性诊断标志物的潜力。
4. **文献名称**: *"Antibody-mediated Inhibition of ENOX2 Attenuates Tumor Growth in Mouse Models"*
**作者**: Lee et al. (2019)
**摘要**: 研究显示，ENOX2 (N-term)抗体可通过阻断ENOX2的氧化还原酶活性抑制肿瘤血管生成，在动物模型中显著降低肿瘤体积。
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“ENOX2 antibody”或“ENOX2 N-terminal”。
The ENOX2 (N-term) antibody is designed to target the N-terminal region of ENOX2 (ecto-NOX disulfide-thiol exchanger 2), a cell surface-associated oxidase involved in electron transport and cell cycle progression. ENOX2. also known as tumor-associated NOX (tNOX), belongs to the ENOX protein family and is distinct from its homolog ENOX1 (constitutive NOX). It plays a critical role in plasma membrane redox signaling, facilitating NADH oxidation and hydroquinone oxidation, which are linked to cellular proliferation and differentiation. ENOX2 is notably overexpressed in cancer cells and is implicated in maintaining the transformed phenotype, making it a potential biomarker and therapeutic target in oncology.
The antibody’s specificity for the N-terminal domain allows researchers to distinguish ENOX2 from other ENOX isoforms, particularly ENOX1. due to sequence divergence in this region. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study ENOX2 expression patterns in normal versus malignant tissues. Studies employing this antibody have contributed to understanding ENOX2’s role in cancer cell growth, apoptosis resistance, and response to chemotherapeutic agents. Additionally, its involvement in circadian redox rhythms and interactions with prion proteins highlights broader implications in neurodegenerative disease research. Validation of the antibody typically includes testing on recombinant ENOX2 and cell lysates to confirm reactivity and absence of cross-reactivity.
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