Rabbit Polyclonal SLC15A3 Antibody

The SLC15A3 antibody targets the solute carrier family 15 member 3 (SLC15A3), a proton-coupled oligopeptide transporter primarily expressed in lysosomal and endosomal membranes. This transporter facilitates the uptake of di- and tripeptides, playing a role in nutrient sensing, immune regulation, and cellular homeostasis. SLC15A3 is implicated in innate immunity, as it modulates lysosomal functions and interacts with Toll-like receptor (TLR) signaling pathways, particularly in macrophages and dendritic cells. Research highlights its involvement in inflammatory responses, viral infections (e.g., SARS-CoV-2), and autoimmune disorders, such as colitis. Antibodies against SLC15A3 are critical tools for studying its expression, localization, and functional mechanisms in disease models. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to explore its role in peptide transport, immune activation, and pathological conditions. Recent studies also suggest its potential as a biomarker or therapeutic target in cancer and neurodegenerative diseases. Commercial SLC15A3 antibodies are typically raised in rabbits or mice, with validation in knockout controls to ensure specificity. Understanding SLC15A3's biology through antibody-based assays contributes to drug development, particularly for therapies targeting peptide transport systems or immune dysregulation.