Rabbit Polyclonal UGT2B15 Antibody

The UGT2B15 antibody is a crucial tool for studying the UDP-glucuronosyltransferase 2B15 (UGT2B15) enzyme, a member of the UGT superfamily responsible for conjugating glucuronic acid to lipophilic substrates, facilitating their excretion. UGT2B15 is primarily expressed in the liver, prostate, and steroid-sensitive tissues, where it plays a key role in metabolizing endogenous compounds like androgens, estrogens, and bile acids, as well as xenobiotics, including drugs and environmental toxins. This isoform’s activity influences hormone homeostasis, drug efficacy, and toxicity, making it clinically relevant in conditions such as prostate cancer, hormone-dependent disorders, and metabolic diseases. Antibodies targeting UGT2B15 enable researchers to detect its expression, localization, and abundance in tissues or cell lines via techniques like Western blotting, immunohistochemistry, or immunofluorescence. They are vital for investigating tissue-specific regulation, polymorphisms (e.g., the UGT2B15*2 variant linked to altered enzymatic activity), and interactions with signaling pathways. Additionally, UGT2B15 antibodies aid in exploring interindividual variability in drug metabolism and disease susceptibility, supporting personalized medicine approaches. Recent studies also highlight its potential role in cancer progression, particularly androgen-dependent malignancies, underscoring the antibody’s utility in both basic research and therapeutic development.