| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Corticosteroid-binding globulin, CBG, Serpin A6, Transcortin, SERPINA6, CBG |
| Entrez GeneID | 866 |
| WB Predicted band size | 45.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SERPINA6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-225 amino acids from the Central region of human SERPINA6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于SERPINA6抗体的3篇示例文献(作者和摘要内容为模拟，供参考)：
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1. **文献名称**: "Development and validation of a monoclonal antibody specific for human SERPINA6/corticosteroid-binding globulin"
**作者**: Smith A, et al.
**摘要**: 本研究报道了一种针对人SERPINA6蛋白的单克隆抗体的开发与验证。该抗体通过ELISA和Western blot验证了高特异性，可用于检测血清中皮质类固醇结合球蛋白(CBG)的水平，并探索其在糖皮质激素代谢调控中的作用。
2. **文献名称**: "SERPINA6 gene polymorphisms and autoimmune adrenal insufficiency: Role of antibody-mediated CBG dysfunction"
**作者**: Lee B, et al.
**摘要**: 文章探讨了SERPINA6基因多态性与自身免疫性肾上腺功能不全的关联。研究发现，特定抗体可能通过干扰CBG与皮质醇的结合能力，导致游离激素水平异常，进而参与疾病进展。
3. **文献名称**: "A novel SERPINA6 antibody-based assay for diagnosing stress-related disorders"
**作者**: Garcia C, et al.
**摘要**: 研究建立了一种基于SERPINA6抗体的检测方法，用于评估慢性应激患者的CBG水平变化。该方法在临床样本中表现出高灵敏度和重复性，为应激相关疾病的生物标志物研究提供了工具。
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**注意**：以上为模拟文献，实际文献需通过PubMed、Web of Science或Google Scholar等平台检索(关键词：SERPINA6 antibody, CBG immunoassay)。建议补充检索年份(如近5年)以获取最新进展。
The SERPINA6 antibody targets the protein encoded by the SERPINA6 gene, which produces corticosteroid-binding globulin (CBG), a key liver-derived glycoprotein responsible for transporting cortisol and progesterone in the bloodstream. CBG regulates the bioavailability of these hormones by binding ~80-90% of circulating cortisol, influencing stress response, metabolism, and immune function. SERPINA6 belongs to the serine protease inhibitor (serpin) superfamily, though its primary role is hormone transport rather than protease inhibition.
Antibodies against SERPINA6/CBG are essential tools in studying hormonal regulation, particularly in conditions like adrenal insufficiency, chronic stress, or metabolic disorders. They enable quantification of CBG levels in plasma or tissue samples via techniques like ELISA, Western blotting, or immunohistochemistry. Altered CBG expression has been linked to obesity, liver disease, and inflammation, making SERPINA6 antibodies valuable for both basic research and clinical diagnostics.
Recent studies also explore SERPINA6 polymorphisms associated with cortisol-related pathologies, including hypertension and depression. By detecting CBG variants or expression changes, these antibodies help unravel the interplay between genetic factors, hormonal dynamics, and disease susceptibility. Their application extends to reproductive health, as CBG levels fluctuate during pregnancy and menopause. Overall, SERPINA6 antibodies serve as critical reagents for understanding endocrine regulation and its clinical implications.
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