| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | ELAV-like protein 2, ELAV-like neuronal protein 1, Hu-antigen B, HuB, Nervous system-specific RNA-binding protein Hel-N1, ELAVL2, HUB |
| Entrez GeneID | 1993 |
| WB Predicted band size | 39.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This ELAVL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from the Central region of human ELAVL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ELAVL2抗体的3篇示例参考文献(注：以下内容为模拟示例，实际文献请通过学术数据库查询)：
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1. **文献名称**: *"ELAVL2 Antibody Validation in Neuronal RNA-Binding Protein Studies"*
**作者**: Smith A, et al.
**摘要**: 该研究验证了ELAVL2抗体的特异性，证明其在免疫组化和Western blot中可有效识别人脑组织中的ELAVL2蛋白，并探讨了其在神经发育中调控mRNA稳定性的作用。
2. **文献名称**: *"Role of ELAVL2 in Alzheimer's Disease: Insights from Antibody-Based Assays"*
**作者**: Lee J, et al.
**摘要**: 利用ELAVL2抗体检测患者脑组织样本，发现ELAVL2表达水平与tau蛋白异常聚集呈负相关，提示其在神经退行性疾病中可能具有保护作用。
3. **文献名称**: *"Development of a Novel Monoclonal Antibody for ELAVL2 with Cross-Species Reactivity"*
**作者**: Garcia R, et al.
**摘要**: 报道了一种新型ELAVL2单克隆抗体的开发，验证了其对小鼠、大鼠和人源ELAVL2蛋白的反应性，并应用于胚胎发育模型中RNA结合蛋白的定位研究。
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如需具体文献，建议通过PubMed、Google Scholar等平台检索关键词“ELAVL2 antibody”或“HuB antibody”(ELAVL2曾用名HuB)。
The ELAVL2 antibody targets the ELAV-like protein 2 (ELAVL2), a member of the Embryonic Lethal Abnormal Vision (ELAVL)/Hu family of RNA-binding proteins. ELAVL2. also known as HuB, plays a critical role in post-transcriptional gene regulation by binding to AU-rich elements in mRNA, influencing stability, splicing, and translation. It is predominantly expressed in neurons and germ cells, where it supports neuronal differentiation, synaptic plasticity, and maintenance of cellular homeostasis.
ELAVL2 antibodies are widely used in neuroscience and cancer research to study protein expression, localization, and function. In neurodegenerative diseases, altered ELAVL2 levels correlate with disrupted RNA metabolism, while in cancers like neuroblastoma and gliomas, its dysregulation may drive tumorigenesis or metastasis. Researchers employ these antibodies in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to explore ELAVL2's role in development, disease mechanisms, and potential therapeutic targeting.
Commercial ELAVL2 antibodies are validated for specificity, often via knockout controls, to ensure accurate detection. Their application extends to biomarker studies, as ELAVL2 expression patterns may serve as diagnostic or prognostic indicators in neurological and oncological contexts.
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