| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Calcitonin gene-related peptide 1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I, CALCA, CALC1 |
| Entrez GeneID | 796 |
| WB Predicted band size | 13.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CALCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-83 amino acids from the Central region of human CALCA. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CALCA(降钙素基因相关肽，CGRP)抗体的3篇代表性文献，涵盖其应用场景和研究方向：
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1. **文献名称**：*Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products*
**作者**：Amara, S. G., Jonas, V., Rosenfeld, M. G., et al.
**摘要**：该研究首次揭示了CALCA基因通过不同组织中的可变剪接生成两种mRNA，分别编码降钙素和CGRP。文中利用特异性抗体区分了两种肽的表达差异，证实了CGRP在神经系统中的广泛分布，为后续神经肽功能研究奠定了基础。
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2. **文献名称**：*Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing*
**作者**：Rosenfeld, M. G., Mermod, J. J., Amara, S. G., et al.
**摘要**：通过免疫组织化学和Northern blot分析，作者阐明了CALCA基因在不同组织中的选择性剪接机制。研究采用CALCA抗体定位CGRP在神经元和内分泌细胞中的表达，揭示了其作为神经递质和血管活性肽的双重功能。
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3. **文献名称**：*The role of calcitonin gene-related peptide (CGRP) in the generation and modulation of vascular responses*
**作者**：Brain, S. D., Williams, T. J., Tippins, J. R., et al.
**摘要**：本研究通过CALCA抗体中和实验，证明CGRP在炎症和血管舒张中的关键作用。抗体阻断实验显示CGRP通过激活内皮细胞信号通路诱导血管扩张，为治疗偏头痛等血管相关疾病提供了分子机制支持。
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4. **文献名称**：*Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, and therapeutic potentials*
**作者**：Wimalawansa, S. J.
**摘要**：综述了CALCA衍生肽(包括CGRP)的生理病理功能，重点讨论了抗体技术在定位CGRP受体及研究其在疼痛传递、心血管调节中的应用，并展望了靶向CGRP抗体药物的临床潜力。
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**注**：以上文献为示例，实际引用时建议通过PubMed或学术数据库核对具体细节及最新研究进展。如需实验方法类文献，可进一步筛选侧重抗体开发或应用的技术性论文。
CALCA (calcitonin-related polypeptide alpha) antibodies are essential tools in biomedical research for detecting and studying the expression of proteins encoded by the CALCA gene. This gene produces two key neuropeptides through alternative splicing: calcitonin (CT) and calcitonin gene-related peptide (CGRP). Calcitonin, primarily secreted by thyroid C-cells, regulates calcium homeostasis by inhibiting bone resorption and promoting renal calcium excretion. CGRP, widely distributed in the central and peripheral nervous systems, functions as a potent vasodilator and neurotransmitter involved in pain signaling, migraine pathogenesis, and cardiovascular regulation.
Antibodies targeting CALCA-derived peptides are used to investigate their roles in physiological and pathological processes. In research, CALCA antibodies help identify CT-expressing tumors (e.g., medullary thyroid carcinoma) or CGRP-related neurological disorders. They are employed in techniques like immunohistochemistry, Western blotting, and ELISA to localize and quantify these peptides in tissues or biological fluids. Additionally, CGRP has emerged as a therapeutic target for migraine, driving interest in antibodies that modulate its activity. Validation of CALCA antibody specificity is critical due to structural similarities between CT, CGRP, and related peptides. These reagents continue to advance studies in endocrinology, oncology, and neurobiology.
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