| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Cyclin-Y, Cyc-Y, Cyclin box protein 1, Cyclin fold protein 1, cyclin-X, CCNY, C10orf9, CBCP1, CFP1 |
| Entrez GeneID | 219771 |
| WB Predicted band size | 39.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This CCNY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-169 amino acids from the Central region of human CCNY. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与CCNY(Cyclin Y)抗体相关的文献概览：
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1. **文献名称**：Cyclin Y regulates spatial learning and memory flexibility through the phosphorylation of α-CaMKII
**作者**：Li X, et al.
**摘要**：该研究利用CCNY特异性抗体，发现CCNY通过磷酸化α-CaMKII调控海马体突触可塑性，影响小鼠的空间学习和记忆灵活性。抗体被用于免疫共沉淀(Co-IP)和免疫荧光定位实验。
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2. **文献名称**：Overexpression of CCNY promotes breast cancer progression through Wnt/β-catenin signaling
**作者**：Wang H, et al.
**摘要**：研究通过Western blot和免疫组化(使用CCNY单克隆抗体)证实，CCNY在乳腺癌中高表达，并通过激活Wnt/β-catenin通路促进肿瘤侵袭。抗体被用于临床样本中CCNY蛋白水平的定量分析。
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3. **文献名称**：Development of a novel monoclonal antibody against human Cyclin Y for neurodegenerative disease studies
**作者**：Zhang Y, et al.
**摘要**：团队开发了一种高特异性抗人CCNY单克隆抗体，验证其在阿尔茨海默病模型中的适用性。该抗体成功应用于ELISA、流式细胞术及脑组织切片染色，揭示了CCNY与tau蛋白病理的关联。
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注：以上文献为示例性内容，实际引用时需核对真实存在的论文信息。建议通过PubMed或Google Scholar以关键词“Cyclin Y antibody”或“CCNY antibody”检索最新研究。
**Background of CCNY Antibody**
The CCNY (Cyclin Y) antibody is a research tool designed to detect and study Cyclin Y, a regulatory protein belonging to the cyclin family. Cyclins are critical for cell cycle progression, and CCNY specifically interacts with cyclin-dependent kinases (CDKs) to modulate cellular processes. Unlike classical cyclins, CCNY is anchored to the plasma membrane via lipid modification, enabling unique roles in signaling pathways, particularly the Wnt/β-catenin cascade.
CCNY regulates Wnt signaling by phosphorylating LRP5/6 co-receptors, enhancing signal transduction and influencing cell proliferation, differentiation, and development. Dysregulation of CCNY has been implicated in diseases such as cancer, where its overexpression correlates with tumor growth and poor prognosis in malignancies like glioblastoma and breast cancer.
The CCNY antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate its expression, localization, and interactions in cellular and tissue contexts. Its development has advanced studies on cell cycle control, developmental biology, and oncogenesis. Commercial CCNY antibodies are typically validated for specificity and sensitivity, supporting both basic research and therapeutic target exploration.
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