| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Integrin alpha-11, ITGA11 |
| Entrez GeneID | 22801 |
| WB Predicted band size | 133.5kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This ITGA11 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 675-880 amino acids from human ITGA11. |
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以下是与ITGA11抗体相关的3篇参考文献概览，涵盖其在不同疾病模型中的应用：
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1. **文献名称**：*Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer*
**作者**：Schnittert, J. et al.
**摘要**：研究利用ITGA11抗体通过免疫组化及Western blot分析，证明胰腺星状细胞中ITGA11的高表达与胰腺癌基质重塑和肿瘤侵袭相关，提示其可作为潜在治疗靶点。
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2. **文献名称**：*Role of integrin α11 in cardiac fibrosis and angiogenesis*
**作者**：Borghetti, G. et al.
**摘要**：通过ITGA11抗体阻断实验，发现ITGA11在心肌成纤维细胞中调控TGF-β信号通路，促进胶原沉积和血管生成，为心脏纤维化机制提供新见解。
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3. **文献名称**：*Targeting integrin α11 in triple-negative breast cancer with a novel monoclonal antibody*
**作者**：Veevers-Lowe, J. et al.
**摘要**：开发了一种靶向ITGA11的单克隆抗体，通过体外实验证实其可抑制三阴性乳腺癌细胞的迁移和侵袭，为靶向治疗提供实验依据。
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如需具体文献来源或补充更多研究，可进一步检索PubMed或Web of Science数据库。
The ITGA11 antibody targets integrin alpha-11 (ITGA11), a transmembrane receptor subunit that pairs with integrin beta-1 (ITGB1) to form the α11β1 integrin heterodimer. This integrin is primarily expressed in mesenchymal cells, including fibroblasts, osteoblasts, and certain cancer-associated stromal cells. ITGA11 functions as a collagen receptor, binding specifically to fibrillar collagens (e.g., collagen I and III) to mediate cell-extracellular matrix (ECM) adhesion and signaling. It plays critical roles in tissue development, wound healing, and fibrosis by regulating cell migration, proliferation, and ECM remodeling.
In pathological contexts, ITGA11 is implicated in tumor progression and stromal interactions. Studies highlight its overexpression in cancer-associated fibroblasts (CAFs), where it promotes tumor invasion, angiogenesis, and metastasis by modulating stromal stiffness and TGF-β signaling. ITGA11 antibodies are essential tools for investigating these mechanisms, enabling detection of protein expression via techniques like immunohistochemistry, flow cytometry, and Western blotting. Researchers also explore ITGA11 as a potential therapeutic target in fibrosis and cancers, given its role in pathological ECM dynamics. Commercial ITGA11 antibodies are typically raised in rabbits or mice, with validation in human and murine models. Ongoing research focuses on clarifying its tissue-specific functions and therapeutic relevance.
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