Rabbit Polyclonal Stanniocalcin-2(STC2)(N-term) Antibody

Stanniocalcin-2 (STC2) is a secreted glycoprotein belonging to the stanniocalcin family, evolutionarily conserved across vertebrates. It plays roles in calcium-phosphate homeostasis, cellular stress responses, and modulation of growth signaling pathways. STC2 is implicated in diverse physiological and pathological processes, including cancer progression, metabolic regulation, and tissue development. Its overexpression is associated with tumorigenesis, where it promotes cell survival, angiogenesis, and resistance to chemotherapy or radiation. The N-terminal region of STC2 contains critical functional domains involved in protein maturation, receptor interaction, and biological activity. Antibodies targeting the N-terminus of STC2 (STC2 (N-term)) are valuable tools for detecting endogenous STC2 in research applications such as Western blotting, immunohistochemistry, and immunofluorescence. These antibodies specifically recognize epitopes within the first 50-100 amino acids of the protein, enabling differentiation from its homolog STC1 and ensuring specificity in experimental models. Validation often includes reactivity confirmation in knockout cell lines or tissues. STC2 (N-term) antibodies are widely used in cancer biology studies to explore STC2's role in tumor microenvironments, metastasis, and as a potential biomarker. Their utility extends to investigating STC2's involvement in endoplasmic reticulum stress responses and metabolic diseases like diabetes.