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Rabbit Polyclonal MSL1 Antibody

  • 中文名: MSL1抗体
  • 别    名: Male-specific lethal 1 homolog, MSL-1, Male-specific lethal 1-like 1, MSL1-like 1, Male-specific lethal-1 homolog 1, MSL1, MSL1L1
货号: IPDX34724
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesMale-specific lethal 1 homolog, MSL-1, Male-specific lethal 1-like 1, MSL1-like 1, Male-specific lethal-1 homolog 1, MSL1, MSL1L1
Entrez GeneID339287
WB Predicted band size67.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis MSL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 339-367 amino acids from the Central region of human MSL1.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于MSL1抗体的3篇参考文献示例(文献信息为模拟概括,仅供参考):

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1. **文献名称**: *"The Drosophila MSL complex acetylates histone H4K16 on the male X chromosome for dosage compensation"*

**作者**: Smith, E.R., et al.

**摘要**: 本研究利用MSL1特异性抗体通过ChIP-seq技术,揭示了果蝇MSL复合体在雄性X染色体上乙酰化组蛋白H4K16的机制,证明了MSL1抗体在定位复合体结合位点中的关键作用。

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2. **文献名称**: *"Characterization of MSL1 interaction partners in mammalian cells using co-immunoprecipitation"*

**作者**: Brown, T., et al.

**摘要**: 通过MSL1抗体进行免疫共沉淀实验,鉴定了哺乳动物细胞中MSL1与MOF乙酰转移酶等蛋白的相互作用,提示其在表观遗传调控中的保守功能。

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3. **文献名称**: *"Developmental regulation of MSL1 expression in Drosophila embryos"*

**作者**: Lee, J., & Kim, S.

**摘要**: 该研究使用MSL1抗体进行免疫荧光染色,发现MSL1在果蝇胚胎发育早期特异性表达于雄性细胞核,支持其在性别特异性剂量补偿中的必要性。

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**备注**:实际文献需通过数据库(如PubMed、Google Scholar)检索确认。建议结合关键词“MSL1 antibody”或“MSL complex”查找具体应用场景(如Western blot、ChIP等)。

背景信息

The MSL1 antibody is a key tool in studying the Male-Specific Lethal (MSL) complex, a conserved epigenetic regulator in *Drosophila melanogaster*. The MSL complex, composed of MSL1. MSL2. MSL3. Male-less (MLE), and non-coding roX RNAs, mediates dosage compensation in male flies by selectively enhancing transcription from the single X chromosome to balance gene expression between males (XY) and females (XX). MSL1 serves as a scaffolding protein critical for complex assembly and targeting to X-chromosomal loci. It interacts with MSL2 to recruit histone acetyltransferase MOF, promoting H4K16 acetylation—a hallmark of active chromatin. Antibodies against MSL1 are widely used to investigate the complex’s localization, dynamics, and functional roles via techniques like chromatin immunoprecipitation (ChIP), immunofluorescence, and Western blotting. Studies leveraging MSL1 antibodies have revealed insights into chromatin remodeling, transcriptional regulation, and sex-specific gene expression. Additionally, they aid in exploring evolutionary conservation of dosage compensation mechanisms and potential links to human diseases involving chromatin dysregulation. The antibody’s specificity and reliability make it indispensable for dissecting the interplay between epigenetic machinery and genome-wide transcriptional control in model organisms.

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