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Rabbit Polyclonal PCDH9 Antibody

  • 中文名: PCDH9抗体
  • 别    名: Protocadherin-9, PCDH9
货号: IPDX34723
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesProtocadherin-9, PCDH9
Entrez GeneID5101
WB Predicted band size136.1kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis PCDH9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1018-1046 amino acids from the C-terminal region of human PCDH9.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是关于PCDH9抗体的3篇虚构参考文献示例(实际文献需通过学术数据库检索确认):

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1. **文献名称**: *PCDH9 expression in gliomas and its prognostic significance*

**作者**: Smith A, et al.

**摘要**: 研究通过免疫组化分析PCDH9蛋白在神经胶质瘤中的表达,发现低表达与患者生存期缩短相关,提示其可能作为肿瘤抑制因子及预后标志物。

2. **文献名称**: *PCDH9 regulates synaptic plasticity in hippocampal neurons*

**作者**: Lee JH, et al.

**摘要**: 利用Western blot和免疫荧光技术,证实PCDH9抗体标记的蛋白在海马神经元突触中富集,敲除后导致突触可塑性异常,表明其对神经环路发育的关键作用。

3. **文献名称**: *Loss of PCDH9 promotes metastasis in colorectal cancer*

**作者**: Zhang Y, et al.

**摘要**: 通过免疫组化分析结直肠癌组织,发现PCDH9表达缺失与侵袭转移增强相关,体外实验显示其通过调控Wnt/β-catenin通路抑制肿瘤迁移。

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**注意**:以上为模拟示例,实际文献请通过PubMed、Google Scholar等平台检索关键词“PCDH9 antibody”或“PCDH9 function”获取。

背景信息

The protocadherin-9 (PCDH9) antibody is a tool used to study the PCDH9 protein, a member of the protocadherin family involved in cell-cell adhesion and signaling. Protocadherins are calcium-dependent transmembrane proteins critical for neural development, synaptic specificity, and tissue morphogenesis. PCDH9. located on chromosome 13. is predominantly expressed in the central nervous system and plays roles in axon guidance, neuronal connectivity, and synaptic plasticity. Dysregulation of PCDH9 has been linked to neurodevelopmental disorders, including autism spectrum disorders (ASD), and certain cancers, such as glioblastoma and hepatocellular carcinoma, where it may act as a tumor suppressor or promoter depending on context. The PCDH9 antibody enables detection and localization of the protein in tissues or cultured cells via techniques like Western blot, immunohistochemistry, and immunofluorescence. Research using this antibody has explored its involvement in cancer metastasis, neuronal circuit formation, and epigenetic regulation. However, functional studies remain ongoing to clarify its precise mechanisms in health and disease. Commercial PCDH9 antibodies are typically validated for specificity, though variability in isoforms and post-translational modifications requires careful experimental optimization.

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