| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Hydroperoxide isomerase ALOXE3, Epidermis-type lipoxygenase 3, Epidermal LOX-3, e-LOX-3, eLOX-3, Hydroperoxy icosatetraenoate dehydratase, ALOXE3 |
| Entrez GeneID | 59344 |
| WB Predicted band size | 80.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This ALOXE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-252 amino acids from the Central region of human ALOXE3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于ALOXE3抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *Mutations in ALOXE3 cause autosomal recessive congenital ichthyosis*
**作者**: Eckl KM, et al.
**摘要**: 该研究通过基因测序发现ALOXE3基因突变与常染色体隐性先天性鱼鳞病(ARCI)相关。研究者利用特异性ALOXE3抗体进行免疫组化分析，发现突变导致表皮脂氧合酶功能丧失，破坏皮肤屏障完整性。
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2. **文献名称**: *ALOXE3 deficiency in mice leads to epidermal hyperproliferation and inflammation*
**作者**: Yu Z, et al.
**摘要**: 研究通过构建ALOXE3基因敲除小鼠模型，结合ALOXE3抗体进行蛋白表达检测，发现ALOXE3缺失导致表皮过度增生和炎症反应，证实其在维持皮肤脂质代谢稳态中的关键作用。
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3. **文献名称**: *Lipoxygenase enzymes and epidermal ceramide synthesis: Role of ALOXE3 in barrier function*
**作者**: Ohno Y, et al.
**摘要**: 本文探讨脂氧合酶家族(包括ALOXE3)在表皮神经酰胺合成中的作用。通过ALOXE3抗体标记实验，揭示其在角质层脂质层重组中的定位，并证明其功能异常与皮肤屏障缺陷相关。
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如需具体文献链接或补充信息，可进一步提供研究方向或数据库检索关键词。
The ALOXE3 antibody targets the enzyme arachidonate lipoxygenase 3 (ALOXE3), a member of the lipoxygenase family involved in epidermal lipid metabolism. ALOXE3. along with ALOX12B, plays a critical role in synthesizing specialized pro-resolving lipid mediators essential for maintaining skin barrier integrity. These enzymes catalyze the oxidation of polyunsaturated fatty acids, contributing to the formation of ceramide esters in the stratum corneum, which prevent transepidermal water loss. Mutations in the ALOXE3 gene are linked to autosomal recessive congenital ichthyosis (ARCI), a severe genetic skin disorder characterized by thickened, scaly skin due to impaired barrier function.
ALOXE3 antibodies are primarily used in research to study the molecular mechanisms underlying skin differentiation, barrier formation, and inflammatory responses. They enable detection of ALOXE3 expression in tissues via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding in the investigation of pathological conditions such as ichthyosis, eczema, or psoriasis. Additionally, these antibodies help assess protein localization and interaction partners, providing insights into ALOXE3's role in lipid signaling pathways and cross-talk with other epidermal proteins. Their diagnostic potential includes identifying ALOXE3 deficiency or dysfunction in clinical samples. As therapeutic strategies targeting lipid mediators evolve, ALOXE3 antibodies remain vital tools for understanding skin biology and developing treatments for barrier-related diseases.
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