Rabbit Polyclonal SLCO1B1 Antibody

The SLCO1B1 gene encodes the organic anion-transporting polypeptide 1B1 (OATP1B1), a membrane transporter protein primarily expressed in hepatocytes. It facilitates the uptake of endogenous compounds (e.g., bilirubin, hormones) and xenobiotics, including many drugs (e.g., statins, antibiotics), from blood into the liver for metabolism or excretion. Antibodies targeting SLCO1B1 are critical tools for studying its expression, localization, and function in physiological and pathological contexts. Research using these antibodies has highlighted the clinical relevance of SLCO1B1 polymorphisms, particularly the rs4149056 (c.521T>C) variant, which reduces transporter activity and is linked to increased systemic drug exposure and adverse effects (e.g., statin-induced myopathy). SLCO1B1 antibodies are employed in techniques like immunohistochemistry, Western blotting, and flow cytometry to assess protein levels in liver tissues or cell models, aiding pharmacogenomic studies and personalized medicine approaches. They also support investigations into diseases associated with OATP1B1 dysfunction, such as hyperbilirubinemia and drug-drug interactions. Commercial SLCO1B1 antibodies are typically validated for specificity using knockout controls or overexpression systems. However, variability in antibody performance across experimental conditions remains a challenge, emphasizing the need for rigorous validation in target applications.