Rabbit Polyclonal SMPD1 Antibody

SMPD1 (sphingomyelin phosphodiesterase 1) antibodies are immunological tools targeting the enzyme acid sphingomyelinase (ASM), encoded by the *SMPD1* gene. ASM plays a critical role in sphingolipid metabolism by hydrolyzing sphingomyelin into ceramide and phosphocholine, influencing cellular processes like apoptosis, inflammation, and membrane dynamics. Dysregulation of SMPD1 is linked to Niemann-Pick disease types A and B (lysosomal storage disorders caused by ASM deficiency), atherosclerosis, cancer, and neurodegenerative conditions. Antibodies against SMPD1 are widely used in research to detect protein expression, localization, and activity in tissues or cells. They aid in studying ASM's role in disease mechanisms, drug responses, and lipid signaling pathways. For example, SMPD1 antibodies help validate ASM levels in models of lysosomal dysfunction or assess ceramide-mediated pathways in cancer therapy resistance. Commercial SMPD1 antibodies are typically developed in hosts like rabbits or mice, validated for applications such as Western blotting, immunohistochemistry, and ELISA. However, variability in specificity and cross-reactivity requires careful validation. Recent studies also explore SMPD1 as a therapeutic target, with antibodies supporting biomarker discovery or inhibitor development. Overall, SMPD1 antibodies remain vital for unraveling the enzyme's biological and pathological significance.