| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mitogen-activated protein kinase kinase kinase 13, Leucine zipper-bearing kinase, Mixed lineage kinase, MLK, MAP3K13 (HGNC:6852) |
| Entrez GeneID | 9175 |
| WB Predicted band size | 108.3kDa |
| Host/Isotype | Mouse IgM |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified His-tagged MAP3K13 protein fragment was used to produced this monoclonal antibody. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于 MAP3K13 (LZK) 抗体的3篇代表性文献，按研究领域分类简要总结：
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1. **文献名称**：*MAP3K13 is a critical driver of anti-tumor T cell response and immune checkpoint therapy*
**作者**：Li Y, et al.
**摘要**：本研究通过基因筛选发现，MAP3K13在T细胞中调控抗肿瘤免疫应答，其抗体用于验证蛋白表达水平。实验表明，MAP3K13缺失会增强T细胞功能并提高PD-1抑制剂疗效。
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2. **文献名称**：*LZK mediates neurodegenerative pathways in Parkinson’s disease models*
**作者**：Smith J, et al.
**摘要**：利用MAP3K13抗体检测帕金森病模型中LZK蛋白的激活状态，发现其通过JNK通路促进神经元凋亡，抗体特异性验证为关键实验依据。
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3. **文献名称**：*MAP3K13 regulates glioblastoma invasion via EMT signaling*
**作者**：Chen R, et al.
**摘要**：在胶质母细胞瘤研究中，使用MAP3K13抗体进行免疫组化和Western blot分析，揭示其通过调控上皮间质转化(EMT)驱动肿瘤侵袭。
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**备注**：上述文献均为虚构示例，实际引用需查询PubMed或Google Scholar(关键词：MAP3K13/LZK antibody + cancer/neurodegeneration)。建议优先选择近5年研究，并关注抗体应用场景(如验证、定位或功能研究)。
The MAP3K13 (LZK) antibody is a tool for detecting the mitogen-activated protein kinase kinase kinase 13 (MAP3K13), also known as leucine zipper-bearing kinase (LZK). This serine/threonine kinase belongs to the MAP3K family, which regulates stress-activated signaling pathways, including JNK and p38 MAPK cascades. MAP3K13 plays roles in cellular responses to stress, apoptosis, inflammation, and neuronal development. It is implicated in neurodegenerative diseases, cancer, and tissue injury repair, with studies highlighting its dual role in promoting neuronal survival or death depending on context.
The antibody is commonly used in research to study MAP3K13 expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity is validated through knockdown/knockout controls to ensure accurate detection of the ~180 kDa protein. MAP3K13 antibodies are critical for exploring mechanisms in neuroprotection, axon regeneration, and tumor progression, particularly in cancers like hepatocellular carcinoma where MAP3K13 may drive proliferation. Recent studies also link MAP3K13 to non-canonical NF-κB activation, expanding its relevance in immune regulation. Available as monoclonal or polyclonal versions, these antibodies enable investigations into tissue-specific signaling and therapeutic targeting of MAP3K13-associated pathways.
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