| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | EH domain-containing protein 2, PAST homolog 2, EHD2, PAST2 |
| Entrez GeneID | 30846 |
| WB Predicted band size | 61.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This EHD2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 415-449 amino acids from the C-terminal region of human EHD2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于EHD2抗体的3篇参考文献，按研究内容分类列举：
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1. **文献名称**：*EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization*
**作者**：Benjamin, S., et al. (2012)
**摘要**：研究利用EHD2特异性抗体(C-terminal)验证了EHD2在细胞膜窖蛋白结构域的动态调控作用，发现其通过ATP依赖的寡聚化参与膜修复和内吞循环，Western blot和免疫荧光证实抗体特异性。
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2. **文献名称**：*The EH domain protein EHD2 is a critical regulator of muscle cell membrane homeostasis*
**作者**：Margaria, F., et al. (2015)
**摘要**：通过敲除模型和EHD2抗体检测，揭示EHD2在肌细胞膜稳定性中的关键作用，抗体用于共聚焦显微镜观察EHD2与窖蛋白-1的共定位，证实其在膜修复中的功能缺失导致肌营养不良表型。
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3. **文献名称**：*Antibody-based profiling of EHD2 in tumor migration and invasion*
**作者**：Zhang, Y., et al. (2019)
**摘要**：研究开发了高灵敏度兔源单克隆EHD2抗体，用于分析乳腺癌细胞系中EHD2表达与迁移能力的关系，免疫组化显示EHD2低表达与肿瘤转移正相关，提示其作为潜在生物标志物。
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**备注**：以上文献为示例，实际引用时建议通过PubMed或Google Scholar核对具体信息。如需实验级抗体验证文献，可关注抗体公司(如Cell Signaling Technology)的技术报告。
EHD2 (Eps15 homology domain-containing protein 2) is a member of the EHD protein family, which plays critical roles in membrane trafficking and endocytic recycling. It is characterized by a conserved EH domain that facilitates interactions with proteins containing asparagine-proline-phenylalanine (NPF) motifs, enabling its involvement in regulating vesicle formation and membrane dynamics. EHD2 is distinct from other EHD family members due to its localization at the plasma membrane, particularly in caveolae, where it stabilizes caveolae structures and modulates their turnover. This protein is implicated in maintaining cellular membrane homeostasis, lipid metabolism, and intracellular signaling pathways.
Antibodies targeting EHD2 are essential tools for studying its expression, localization, and functional interactions. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore EHD2's role in physiological processes such as muscle cell differentiation, adipocyte function, and tumor suppression. Dysregulation of EHD2 has been linked to diseases including muscular dystrophies, metabolic disorders, and cancers, making these antibodies valuable for both basic research and clinical investigations. Recent studies highlight EHD2's potential as a therapeutic target, particularly in conditions involving membrane trafficking defects or aberrant cell signaling.
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