| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/250 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Sialidase-2, Cytosolic sialidase, N-acetyl-alpha-neuraminidase 2, NEU2 |
| Entrez GeneID | 4759 |
| WB Predicted band size | 42.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This NEU2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-50 amino acids from the N-terminal region of human NEU2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NEU2(N-term)抗体的3篇模拟参考文献(注：内容为示例，非真实文献)：
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1. **文献名称**：*Characterization of a Novel N-Terminal Specific NEU2 Antibody in Cancer Cell Lines*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种针对NEU2蛋白N端表位的高特异性单克隆抗体，通过免疫印迹和免疫组化验证其在多种癌细胞系中的表达差异，证实NEU2在结肠癌中高表达且与转移相关。
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2. **文献名称**：*NEU2 Knockout Mice Reveal Neuraminidase-2's Role in Neuronal Development via N-Terminal Antibody Staining*
**作者**：Li H, et al.
**摘要**：利用NEU2(N-term)抗体对基因敲除小鼠脑组织进行染色，发现NEU2通过调节神经节苷脂代谢影响突触形成，提示其在中枢神经系统发育中的关键作用。
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3. **文献名称**：*Development and Validation of an ELISA Assay Using NEU2 N-Terminal Antibody for Early Cancer Diagnosis*
**作者**：Garcia R, et al.
**摘要**：基于NEU2(N-term)抗体建立了一种高灵敏度ELISA检测方法，可在血清中定量NEU2蛋白水平，实验显示其在胰腺癌早期患者中显著升高，具有临床诊断潜力。
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提示：实际文献需通过PubMed、Google Scholar等平台以“NEU2 antibody”、“NEU2 N-terminal”等关键词检索。
NEU2 (N-term) antibody is a polyclonal or monoclonal antibody specifically designed to target the N-terminal region of human neuraminidase 2 (NEU2), a key enzyme in the sialidase family. NEU2. also known as cytosolic sialidase, catalyzes the removal of terminal sialic acid residues from glycoproteins and glycolipids, regulating cellular processes such as cell signaling, adhesion, and metabolism. Unlike other neuraminidase isoforms (NEU1. NEU3. NEU4), NEU2 is primarily localized in the cytosol and is implicated in lysosome-independent degradation pathways.
The NEU2 (N-term) antibody is commonly used in molecular and cellular biology research to study NEU2 expression, localization, and function. It is validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity for the N-terminal region ensures recognition of full-length or truncated NEU2 variants, aiding in investigations of NEU2-related pathologies, including cancer, neurodegenerative disorders, and metabolic diseases. Dysregulation of NEU2 has been linked to abnormal glycosylation patterns in tumors and impaired neural development, making this antibody a valuable tool for exploring disease mechanisms.
Developers often validate the antibody using NEU2-overexpressing cell lines or knockout controls to confirm reactivity. Its utility extends to both diagnostic and therapeutic research, particularly in understanding how sialidase activity influences cellular interactions and disease progression.
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