Rabbit Polyclonal GLRX2(C-termT135) Antibody

The GLRX2 (C-term T135) antibody is a specialized tool designed to detect the C-terminal region of glutaredoxin-2 (GLRX2), a critical redox-regulating protein involved in maintaining cellular oxidative balance. GLRX2 belongs to the glutaredoxin family, which facilitates disulfide bond reduction and iron-sulfur cluster assembly, playing pivotal roles in mitochondrial function, antioxidant defense, and apoptosis regulation. The antibody specifically targets a sequence near the C-terminus, including residue threonine 135 (T135), which may be post-translationally modified or involved in protein interactions. This antibody is commonly used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study GLRX2 expression, localization, and function in various tissues and disease models, particularly in contexts of oxidative stress, neurodegeneration, or cancer. Its specificity is often validated using knockout controls or peptide-blocking assays. Research employing this antibody has contributed to understanding GLRX2's role in mitigating mitochondrial dysfunction, modulating redox signaling, and influencing cell survival pathways. Commercial versions may vary in host species, clonality, and conjugate tags, with validation data typically provided in product specifications.