Mouse Monoclonal GDE1 Antibody

The GDE1 (glycerophosphodiester phosphodiesterase 1) antibody is a research tool designed to detect and study the GDE1 protein, a transmembrane enzyme involved in glycerophospholipid metabolism and cellular signaling. GDE1 hydrolyzes extracellular glycerophosphodiester bonds, releasing bioactive molecules like glycerol-3-phosphate, which may influence metabolic pathways or signaling cascades. It is expressed in various tissues, including the brain, where it has been implicated in neuronal development, survival, and synaptic plasticity. Studies suggest GDE1 interacts with lipid rafts and modulates pathways such as Rac1 activation, affecting cytoskeletal dynamics and cell migration. Dysregulation of GDE1 is linked to neurological disorders, including Alzheimer’s disease and amyotrophic lateral sclerosis (ALS), as well as cancer progression. The GDE1 antibody enables researchers to investigate its expression, localization, and functional roles through techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its development has been critical for elucidating GDE1’s contribution to membrane-associated processes and disease mechanisms, offering potential insights for therapeutic targeting. Commercial GDE1 antibodies are typically validated for specificity and sensitivity across human, mouse, and rat models.