Rabbit Polyclonal RARA Antibody

The retinoic acid receptor alpha (RARA) is a nuclear hormone receptor that regulates gene expression by binding to retinoic acid response elements (RAREs) in DNA. As a member of the steroid/thyroid hormone receptor superfamily, RARA plays a critical role in cellular differentiation, apoptosis, and development, particularly in hematopoiesis and embryogenesis. It functions by forming heterodimers with retinoid X receptors (RXRs) and recruiting co-activators or co-repressors to modulate transcription in a ligand-dependent manner. RARA is a key therapeutic target in acute promyelocytic leukemia (APLC), where chromosomal translocations (e.g., PML-RARA fusion) disrupt its normal function, leading to blocked differentiation. Antibodies targeting RARA are essential tools for studying its expression, localization, and interactions in both physiological and pathological contexts. They are widely used in techniques like Western blot, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to investigate RARA's role in cancer, developmental disorders, and retinoid signaling pathways. Commercial RARA antibodies are typically validated for specificity using knockout cell lines or competitive assays. Recent research also explores RARA aberrations in solid tumors and resistance mechanisms to retinoid-based therapies, highlighting its broader oncogenic relevance beyond APLC.