关键信息
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基因名
GCN5L2
- 应用
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别名
GCN5L2；GCN5；GCN5L2;Histone acetyltransferase KAT2A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92830
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表达区间
323-837aa
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氨基酸序列
RSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFLSMLEEEIYGANS PIWESGFTMPPSEGTQLVPRPASVSAAVVPSTPIFSPSMGGGSNSSLSLD SAGAEPMPGEKRTLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAM LGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVG LQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQG FTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHNILYFLTYADEYAIGYF KKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQK EIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKE KGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFP IDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALE KFFYFKLKEGGLIDK
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分子量
82 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GCN5L2 (General Control Non-repressible 5 Like 2) is a histone acetyltransferase that plays a significant role in the regulation of gene expression and chromatin remodeling. As an important member of the GNAT (Gcn5-related N-acetyltransferase) superfamily, GCN5L2 is involved in various cellular processes, including cell cycle regulation, differentiation, and response to environmental stresses. Recent studies have highlighted its potential implications in cancer, neurodegenerative diseases, and metabolic disorders, underscoring its importance in maintaining cellular homeostasis. The recombinant protein GCN5L2 has emerged as a valuable tool for investigating the enzyme's mechanisms of action, substrate specificity, and functional interactions with other proteins in the acetylation pathway. By producing and characterizing this recombinant protein, researchers can elucidate the biological roles of GCN5L2 in different physiological contexts and explore its potential as a therapeutic target. The development of specific inhibitors or modulators of GCN5L2 activity could provide novel strategies for the treatment of diseases associated with dysregulated acetylation processes. Thus, understanding the structure and function of GCN5L2 not only expands our knowledge of epigenetic regulation but also paves the way for innovative therapeutic interventions in various diseases.
