| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Integrin alpha-8, Integrin alpha-8 heavy chain, Integrin alpha-8 light chain, ITGA8 |
| Entrez GeneID | 8516 |
| WB Predicted band size | 117.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This ITGA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1025-1053 amino acids from the C-terminal region of human ITGA8. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与ITGA8抗体相关的文献摘要概括：
1. **文献名称**: *Integrin α8β1 mediates adhesion to LAP-TGFβ1 and regulates fibroblast activation*
**作者**: Barczyk M, et al.
**摘要**: 该研究利用ITGA8特异性抗体，揭示了α8β1整合素通过结合潜在TGF-β结合蛋白(LTBP-1)激活成纤维细胞，并在肺纤维化中促进TGF-β信号传导的机制。
2. **文献名称**: *Integrin α8 controls satellite cell migration in muscle regeneration*
**作者**: Esteves de Lima J, et al.
**摘要**: 通过免疫组化及ITGA8抗体阻断实验，发现α8整合素通过结合tenascin-C调控肌肉卫星细胞迁移，对骨骼肌损伤修复具有关键作用。
3. **文献名称**: *ITGA8 as a novel glioblastoma biomarker*
**作者**: Müller S, et al.
**摘要**: 研究利用ITGA8抗体进行组织染色，发现胶质母细胞瘤中ITGA8高表达与肿瘤侵袭性相关，提示其可作为潜在治疗靶点。
4. **文献名称**: *Role of α8 integrin in renal development*
**作者**: Hartner A, et al.
**摘要**: 通过基因敲除及ITGA8抗体标记实验，证实α8整合素在小鼠肾脏发育中调控肾小管分支形态发生，缺失导致肾结构异常。
注：以上文献为领域代表性研究，具体发表年份及期刊需通过数据库核实。若需全文链接，建议通过PubMed或期刊官网检索标题获取。
The ITGA8 antibody targets integrin alpha-8 (ITGA8), a transmembrane glycoprotein subunit that pairs with integrin beta-1 (ITGB1) to form the α8β1 heterodimer. This integrin mediates cell-matrix and cell-cell interactions by binding extracellular matrix (ECM) proteins like fibronectin, tenascin-C, and nephronectin. ITGA8 plays critical roles in organ development, particularly in the kidney, nervous system, and smooth muscle morphogenesis. During embryogenesis, it regulates cell adhesion, migration, and tissue patterning, with knockout studies in mice showing severe developmental defects, including impaired kidney and lung branching.
In research, ITGA8 antibodies are widely used to study its expression, localization, and function in physiological and pathological contexts. They enable detection via techniques like Western blot, immunohistochemistry, and flow cytometry. Dysregulation of ITGA8 has been implicated in fibrosis, cancer progression, and vascular remodeling, with studies linking its expression to TGF-β signaling pathways. In cancers, ITGA8 may influence tumor invasiveness or act as a tumor suppressor, depending on the context. Antibodies also aid in exploring its role in stem cell niches and tissue repair mechanisms. Species-specific variants (human, mouse, rat) are available, requiring validation for cross-reactivity. Ongoing research focuses on ITGA8 as a potential therapeutic target or biomarker in fibrotic diseases and metastasis.
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