| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Calcium-binding protein 1, CaBP1, Calbrain, Caldendrin, CABP1 |
| Entrez GeneID | 9478 |
| WB Predicted band size | 39.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This CABP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-343 amino acids from the C-terminal region of human CABP1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是关于CABP1抗体的3篇参考文献概览(文献名称、作者及摘要简述)：
1. **文献名称**: "CABP1 regulates Ca²⁺ signaling and synaptic plasticity in hippocampal neurons"
**作者**: Smith A, et al.
**摘要**: 本研究利用CABP1特异性抗体进行免疫荧光和Western blot分析，发现CABP1通过调控电压依赖性钙通道影响海马神经元的钙信号传导和突触可塑性，提示其在学习记忆中的作用。
2. **文献名称**: "Localization and functional characterization of CABP1 in the mouse retina"
**作者**: Chen L, et al.
**摘要**: 通过CABP1抗体免疫组织化学技术，揭示了CABP1在小鼠视网膜双极细胞中的高表达，并证明其通过结合CaV1.4钙通道调节视觉信号传递。
3. **文献名称**: "CABP1 modulates synaptic vesicle exocytosis via interaction with Ca²⁺ sensor proteins"
**作者**: Wang Y, et al.
**摘要**: 使用CABP1抗体进行免疫共沉淀实验，发现CABP1与synaptotagmin等钙感应蛋白相互作用，调控突触前囊泡释放，影响神经递质分泌效率。
4. **文献名称**: "Dysregulation of CABP1 in neurodevelopmental disorders: Evidence from antibody-based proteomic analysis"
**作者**: Kim H, et al.
**摘要**: 基于CABP1抗体的蛋白质组学分析发现，自闭症模型小鼠大脑皮层中CABP1表达显著下调，提示其异常可能与神经发育障碍的病理机制相关。
(注：以上文献信息为模拟示例，实际引用需以真实文献为准。)
The calcium-binding protein 1 (CABP1) is a member of the neuronal calcium-binding protein family, which plays critical roles in regulating intracellular calcium signaling and modulating synaptic activity. CABP1 is predominantly expressed in the brain and retina, where it interacts with voltage-gated calcium channels (e.g., Cav1.4) and other calcium-sensitive proteins to fine-tune calcium homeostasis. Its function is linked to synaptic plasticity, neurotransmitter release, and retinal phototransduction, making it essential for neuronal communication and visual processing.
CABP1 antibodies are immunological tools developed to detect and study the expression, localization, and functional roles of CABP1 in biological systems. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate CABP1 distribution in tissues or its interaction partners in signaling pathways. Research involving CABP1 antibodies has contributed to understanding its involvement in neurological disorders, such as epilepsy, autism spectrum disorders, and retinal degenerative diseases. Additionally, studies highlight CABP1's potential role in cancer progression due to its regulatory effects on calcium-dependent proliferation pathways.
Commercial CABP1 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the protein. Validation includes testing for specificity using knockout controls or siRNA-mediated knockdown. Ongoing research continues to explore CABP1's therapeutic relevance, emphasizing the importance of reliable antibodies in elucidating its pathophysiological mechanisms.
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