| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Solute carrier family 23 member 1, Na(+)/L-ascorbic acid transporter 1, Sodium-dependent vitamin C transporter 1, hSVCT1, Yolk sac permease-like molecule 3, SLC23A1, SVCT1, YSPL3 |
| Entrez GeneID | 9963 |
| WB Predicted band size | 64.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SLC23A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SLC23A1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
+ +
以下是3篇涉及SLC23A1 (N-term)抗体的参考文献摘要：
---
1. **文献名称**: "Vitamin C transporter Slc23a1 links renal redox signaling to host defense"
**作者**: Michels AJ, et al.
**摘要**: 研究利用SLC23A1 N端特异性抗体，通过免疫印迹和免疫组化分析小鼠肾脏中SVCT1(SLC23A1)的表达，发现其通过调控肾细胞氧化还原状态影响宿主抗感染能力。
---
2. **文献名称**: "Regulation of vitamin C transport by hypoxia and inflammatory mediators in intestinal cells"
**作者**: Subramanian VS, et al.
**摘要**: 通过Western blot和免疫荧光技术，使用抗SLC23A1 N端抗体验证人肠道细胞中该蛋白的表达变化，揭示低氧和炎症因子通过抑制SLC23A1减少维生素C吸收的机制。
---
3. **文献名称**: "Post-translational modifications of the sodium-dependent vitamin C transporter-2 (SVCT2) regulate its surface expression and function"
**作者**: Savini I, et al.
**摘要**: 研究利用SLC23A1 N端抗体对比SVCT1与SVCT2的亚细胞定位差异，发现SVCT1在细胞膜上的稳定性受磷酸化修饰调控，影响维生素C转运效率。
---
这些研究均通过N端特异性抗体验证SLC23A1蛋白表达及功能，聚焦其在维生素C代谢和疾病中的作用。
The SLC23A1 (N-term) antibody is a tool designed to detect the sodium-dependent vitamin C transporter 1 (SVCT1), encoded by the SLC23A1 gene. This transmembrane protein facilitates the active transport of ascorbic acid (vitamin C) in epithelial tissues, particularly in the intestines and kidneys, playing a critical role in maintaining systemic vitamin C homeostasis. The antibody specifically targets the N-terminal region of SVCT1. which is essential for substrate recognition and transporter function.
As a member of the solute carrier family 23. SVCT1 is a 12-transmembrane domain protein, with its N-terminus located extracellularly. Researchers use this antibody to study SVCT1 expression patterns in various tissues, its regulation under physiological or pathological conditions (e.g., oxidative stress, cancer), and its involvement in diseases linked to vitamin C deficiency or genetic mutations. Applications include Western blotting, immunohistochemistry, and immunofluorescence to visualize protein localization.
The SLC23A1 (N-term) antibody is often validated in human, rodent, or other mammalian models, depending on the source. Its specificity is confirmed through knockout controls or peptide blocking assays. Studies utilizing this antibody contribute to understanding vitamin C metabolism, intestinal absorption mechanisms, and potential therapeutic targets for conditions like scurvy, neurodegenerative disorders, or cancers where SVCT1 expression is dysregulated.
×
