Mouse Monoclonal AKT1S1 Antibody

The AKT1S1 antibody is a crucial tool in studying the AKT signaling pathway, which plays a central role in regulating cellular processes such as growth, proliferation, and survival. AKT1S1 (also known as PRAS40. Proline-Rich AKT1 Substrate 1) is a protein that interacts with the mTORC1 complex, acting as both a substrate and a negative regulator. It binds to mTORC1 under nutrient-rich conditions, inhibiting its activity, and is phosphorylated by AKT to release mTORC1 for activation. This dynamic interaction links growth factor signaling to metabolic regulation. Antibodies targeting AKT1S1 are widely used in research to detect expression levels, phosphorylation status, and subcellular localization in various tissues or cell lines. They are essential in elucidating AKT1S1's role in diseases like cancer, diabetes, and neurological disorders, where mTOR/AKT pathway dysregulation is common. Specific AKT1S1 antibodies enable techniques such as Western blotting, immunohistochemistry, and co-immunoprecipitation, helping to identify therapeutic targets or biomarkers. Recent studies also explore its involvement in autophagy, apoptosis, and stress responses. Validated antibodies with high specificity are critical for reproducible experimental outcomes in both basic and translational research contexts.