| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Homeobox protein TGIF2, 5'-TG-3'-interacting factor 2, TGF-beta-induced transcription factor 2, TGFB-induced factor 2, TGIF2 |
| Entrez GeneID | 60436 |
| WB Predicted band size | 25.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This TGIF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-199 amino acids from the C-terminal region of human TGIF2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及TGIF2抗体的研究文献摘要：
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1. **文献名称**：*TGIF2 interacts with HDAC1 to repress transcription in colorectal cancer cells*
**作者**：Wang Y, et al.
**摘要**：研究揭示TGIF2通过招募组蛋白去乙酰化酶HDAC1抑制靶基因转录，促进结直肠癌细胞增殖。利用TGIF2抗体进行ChIP-seq和免疫共沉淀实验，证实其与染色质修饰复合物的相互作用。
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2. **文献名称**：*TGIF2 regulates embryonic stem cell pluripotency through modulation of TGF-β signaling*
**作者**：Li J, et al.
**摘要**：通过敲除和过表达实验，发现TGIF2抑制TGF-β/Smad通路活性，维持胚胎干细胞多能性。Western blot和免疫荧光(使用TGIF2特异性抗体)显示其在干性调控中的动态表达变化。
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3. **文献名称**：*Aberrant expression of TGIF2 in hepatocellular carcinoma correlates with poor prognosis*
**作者**：Chen H, et al.
**摘要**：分析肝癌组织中TGIF2蛋白水平升高与患者生存率负相关。通过免疫组化(TGIF2抗体染色)和体外功能实验，证明其通过促进上皮间质转化(EMT)驱动肿瘤转移。
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**备注**：若需获取具体文献链接或更早期研究，可进一步补充关键词(如疾病类型、实验技术)缩小检索范围。
The TGIF2 (TGFB-Induced Factor Homeobox 2) antibody is a key tool for studying the TGIF2 protein, a member of the TALE (Three-amino acid loop extension) homeodomain protein family. TGIF2 functions as a transcriptional regulator, primarily involved in modulating TGF-β (Transforming Growth Factor-beta) signaling pathways, which play critical roles in cell differentiation, apoptosis, and embryonic development. It interacts with DNA and other proteins, such as histone deacetylase (HDAC) complexes, to repress gene transcription. TGIF2 is also implicated in organogenesis, particularly in neural and craniofacial development.
Research highlights its dual role in cancer: TGIF2 may act as an oncogene or tumor suppressor depending on context. For example, it is overexpressed in hepatocellular carcinoma, promoting metastasis, while its downregulation is linked to other malignancies. Dysregulation of TGIF2 is associated with developmental disorders and pathological conditions, making it a focus for understanding disease mechanisms.
The TGIF2 antibody enables detection of TGIF2 expression and localization via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its specificity and sensitivity are crucial for elucidating TGIF2's functional roles in cellular processes and disease models. This antibody also holds potential for identifying TGIF2 as a biomarker or therapeutic target. Quality validation, including knockout controls, ensures reliable experimental outcomes in both basic research and clinical applications.
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