| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Follistatin-related protein 1, Follistatin-like protein 1, FSTL1, FRP |
| Entrez GeneID | 11167 |
| WB Predicted band size | 35.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This FSTL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-308 amino acids from the C-terminal region of human FSTL1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于FSTL1抗体的代表性文献摘要概括(虚构示例，实际文献需通过数据库验证)：
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1. **文献名称**：*FSTL1 as a novel mediator of cardiac hypertrophy*
**作者**：Oshima Y, et al.
**摘要**：本研究通过Western blot和免疫组化使用FSTL1抗体，发现FSTL1在心肌肥厚模型中显著上调，并证明其通过激活TGF-β信号通路促进心肌细胞肥大。
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2. **文献名称**：*FSTL1 antibody inhibits tumor metastasis via blocking EMT*
**作者**：Tanaka K, et al.
**摘要**：研究开发了针对FSTL1的中和性单克隆抗体，体外实验表明其能有效抑制肿瘤上皮间质转化(EMT)，并降低乳腺癌小鼠模型的肺转移率。
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3. **文献名称**：*Serum FSTL1 as a biomarker in rheumatoid arthritis*
**作者**：Miyamae T, et al.
**摘要**：通过ELISA结合FSTL1特异性抗体，发现类风湿性关节炎患者血清FSTL1水平与疾病活动度正相关，提示其可作为潜在炎症标志物。
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注：以上为示例模板，实际文献需通过PubMed等数据库以“FSTL1 antibody”或“Follistatin-like 1”为关键词检索。建议结合具体研究领域筛选近年高被引论文。
Follistatin-like 1 (FSTL1) is a secreted glycoprotein involved in regulating cellular processes such as inflammation, tissue repair, and immune responses. Structurally, it contains a follistatin-like domain and multiple glycosylation sites, enabling interactions with extracellular matrix components and signaling molecules. FSTL1 is implicated in modulating pathways like TGF-β and BMP, influencing fibrosis, angiogenesis, and apoptosis. Its dysregulation has been linked to cardiovascular diseases, cancer progression, autoimmune disorders, and metabolic conditions.
FSTL1 antibodies are essential tools for detecting and quantifying FSTL1 expression in research and diagnostics. They enable the study of FSTL1's role in disease mechanisms through techniques like Western blot, immunohistochemistry, and ELISA. Some antibodies target specific epitopes or post-translational modifications, aiding in functional studies. Recent studies highlight FSTL1's potential as a biomarker for conditions like heart failure or rheumatoid arthritis, driving interest in therapeutic targeting. However, antibody specificity remains a challenge due to FSTL1's structural complexity and homology with related proteins. Validated antibodies are critical for advancing insights into FSTL1's dual roles in promoting or inhibiting disease pathways, depending on cellular context.
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