| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Matrix metalloproteinase-9, MMP-9, 92 kDa gelatinase, 92 kDa type IV collagenase, Gelatinase B, GELB, 67 kDa matrix metalloproteinase-9, 82 kDa matrix metalloproteinase-9, MMP9, CLG4B |
| Entrez GeneID | 4318 |
| WB Predicted band size | 78.5kDa |
| Host/Isotype | Mouse IgM |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified His-tagged MMP9 protein(Fragment) was used to produced this monoclonal antibody. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇关于MMP9抗体的参考文献(均为虚构示例，仅用于演示格式)：
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1. **文献名称**：*MMP9 Antibody-Based Detection of Tumor Metastasis in Colorectal Cancer*
**作者**：Smith A, et al.
**摘要**：本研究利用MMP9特异性抗体通过免疫组化技术，证实了MMP9在结直肠癌转移组织中的高表达，提示其可作为癌症侵袭性的生物标志物。
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2. **文献名称**：*Neutralizing MMP9 Antibody Attenuates Neuroinflammation in Alzheimer's Disease Models*
**作者**：Chen L, et al.
**摘要**：通过靶向MMP9的中和抗体抑制其蛋白酶活性，显著减轻了阿尔茨海默病小鼠模型的神经炎症反应和血脑屏障损伤。
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3. **文献名称**：*Comparative Analysis of Commercial MMP9 Antibodies for Biomarker Validation*
**作者**：Johnson R, et al.
**摘要**：系统评估了多种市售MMP9抗体的特异性和灵敏度，为心血管疾病患者血清MMP9水平的标准化检测提供了实验依据。
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(注：以上文献为模拟内容，实际引用需查询真实数据库如PubMed。)
Matrix metalloproteinase-9 (MMP9), also known as gelatinase B, is a zinc-dependent endopeptidase belonging to the MMP family. It plays a critical role in degrading extracellular matrix (ECM) components, including collagen and gelatin, facilitating tissue remodeling, wound healing, and immune responses. MMP9 is implicated in pathological processes such as cancer metastasis, inflammation, and cardiovascular diseases. Its dysregulation is associated with tumor invasion, angiogenesis, and plaque instability in atherosclerosis.
MMP9 antibodies are essential tools for detecting and quantifying this enzyme in research and diagnostics. These antibodies are developed using immunogenic regions of the MMP9 protein, often targeting specific domains like the catalytic site or hemopexin-like domain. They enable applications such as Western blotting, immunohistochemistry, ELISA, and flow cytometry to study MMP9 expression, localization, and activity in tissues or biofluids. In cancer research, MMP9 antibodies help assess tumor aggressiveness and metastatic potential. Clinically, they aid in evaluating MMP9 as a biomarker for inflammatory diseases (e.g., rheumatoid arthritis) or monitoring therapeutic responses. Both monoclonal and polyclonal MMP9 antibodies are available, with validation across species (human, mouse, rat). Recent advances include recombinant antibodies and multiplex assays for high-sensitivity detection in complex biological samples.
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