Rabbit Polyclonal FBXL2 Antibody

The FBXL2 antibody is a crucial tool for studying the F-box and leucine-rich repeat protein 2 (FBXL2), a member of the F-box protein family that serves as a substrate-recognition component of the SCF (Skp1-Cullin-F-box) E3 ubiquitin ligase complex. FBXL2 plays a central role in mediating protein ubiquitination and subsequent proteasomal degradation, thereby regulating diverse cellular processes, including cell cycle progression, apoptosis, DNA damage response, and immune signaling. Research has highlighted its involvement in targeting specific substrates, such as the oncoprotein Bcl-2. toll-like receptors (TLRs), and cyclin D2. linking FBXL2 to cancer, inflammatory diseases, and metabolic disorders. The FBXL2 antibody enables the detection and quantification of FBXL2 expression in various experimental models, facilitating studies on its functional mechanisms, tissue distribution, and dysregulation in pathological conditions. It is widely used in techniques like Western blotting, immunoprecipitation, and immunohistochemistry. Recent studies suggest FBXL2 may act as a tumor suppressor in certain cancers by promoting the degradation of oncoproteins, while its downregulation correlates with poor prognosis. However, its context-dependent roles remain under investigation. The antibody's specificity and reliability are critical for elucidating FBXL2's complex regulatory networks and potential therapeutic applications.