Rabbit Polyclonal TRPV1(N-term) Antibody

The TRPV1 (Transient Receptor Potential Vanilloid 1) antibody, specifically targeting the N-terminal region of the TRPV1 protein, is a key tool in studying this non-selective cation channel. TRPV1. also known as the capsaicin receptor, is a polymodal sensor activated by heat (>43°C), acidic pH, endogenous lipid mediators, and capsaicin—the pungent compound in chili peppers. It plays critical roles in nociception, thermosensation, and inflammatory pain signaling, primarily expressed in sensory neurons. The N-terminal domain of TRPV1 (located near the protein's start site) contributes to channel assembly, ligand binding, and modulation by regulatory proteins or post-translational modifications. Antibodies against this region are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect TRPV1 expression, localization, and interactions in tissues or cell models. They help investigate TRPV1's involvement in chronic pain, neuroinflammation, and metabolic disorders, as well as evaluate therapeutic agents targeting this channel. Validation methods for these antibodies often include knockout controls to confirm specificity. Research applications span neurobiology, pain physiology, and drug development, particularly in exploring TRPV1's dual role as a sensor and mediator of pathological conditions.