| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Neutrophil defensin 1, Defensin, alpha 1, HNP-1, HP-1, HP1, HP 1-56, Neutrophil defensin 2, HNP-2, HP-2, HP2, DEFA1, DEF1, DEFA2, MRS |
| Entrez GeneID | 1667;728358 |
| WB Predicted band size | 10.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This DEFA1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 28-62 amino acids from the Central region of human DEFA1. |
+ +
以下是关于DEFA1抗体的3篇模拟参考文献(基于已有知识框架，非真实文献)：
---
1. **文献名称**：*Human neutrophil peptide-1 (DEFA1) enhances bacterial clearance by promoting phagosome-lysozyme fusion in macrophages*
**作者**：Li, X., Zhang, Y., & Wang, H.
**期刊**：*Journal of Immunology* (2020)
**摘要**：本研究揭示了DEFA1抗体在识别中性粒细胞防御素α1(DEFA1)后调控巨噬细胞抗菌功能的作用机制。实验表明，DEFA1通过促进吞噬体与溶酶体的融合，增强细胞内杀菌能力，为抗感染治疗提供了新靶点。
---
2. **文献名称**：*DEFA1 as a potential biomarker for sepsis severity: Correlation with systemic inflammation and organ dysfunction*
**作者**：Chen, L., et al.
**期刊**：*Infection and Immunity* (2019)
**摘要**：通过对脓毒症患者血清的检测，发现DEFA1蛋白水平与疾病严重程度呈正相关。使用特异性DEFA1抗体进行定量分析，证实其可作为评估脓毒症预后的生物标志物，并可能参与过度炎症反应的病理过程。
---
3. **文献名称**：*Autoantibodies against DEFA1 in rheumatoid arthritis: Implications for neutrophil extracellular trap (NET) formation*
**作者**：Müller, S., et al.
**期刊**：*Autoimmunity Reviews* (2021)
**摘要**：该研究在类风湿性关节炎(RA)患者中发现了针对DEFA1的自身抗体，这些抗体可能干扰中性粒细胞胞外诱捕网(NETs)的正常降解，导致自身抗原暴露和慢性炎症。DEFA1抗体检测为RA的免疫病理机制提供了新视角。
---
**注**：以上文献为模拟内容，实际研究中请通过PubMed、Web of Science等数据库检索真实文献。
**Background of DEFA1 Antibody**
DEFA1 (Defensin Alpha 1) is a small antimicrobial peptide belonging to the α-defensin family, primarily expressed in neutrophils. It plays a critical role in innate immunity by disrupting microbial membranes and modulating immune responses. DEFA1 is involved in host defense against bacteria, viruses, and fungi, and its dysregulation has been linked to inflammatory diseases, infections, and certain cancers.
DEFA1 antibodies are immunological tools designed to detect, quantify, or neutralize DEFA1 protein in research and clinical settings. These antibodies, often monoclonal or polyclonal, are generated using recombinant DEFA1 or peptide antigens. They enable studies on DEFA1’s expression patterns, localization, and functional roles in diseases such as inflammatory bowel disease (IBD), sepsis, and chronic obstructive pulmonary disease (COPD). In diagnostics, DEFA1 antibodies may aid in identifying infection-related biomarkers or assessing neutrophil activity.
Recent research also explores DEFA1’s dual role in cancer—exhibiting both tumor-suppressive and pro-tumorigenic effects depending on the context—highlighting the therapeutic potential of targeting DEFA1 pathways. Challenges remain in ensuring antibody specificity due to homology among defensin family members. Overall, DEFA1 antibodies are vital for advancing understanding of innate immunity and developing targeted therapies.
×
