| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | AP-1 complex subunit mu-1, AP-mu chain family member mu1A, Adaptor protein complex AP-1 subunit mu-1, Adaptor-related protein complex 1 subunit mu-1, Clathrin assembly protein complex 1 mu-1 medium chain 1, Clathrin coat assembly protein AP47, Clathrin coat-associated protein AP47, Golgi adaptor HA1/AP1 adaptin mu-1 subunit, Mu-adaptin 1, Mu1A-adaptin, AP1M1, CLTNM |
| Entrez GeneID | 8907 |
| WB Predicted band size | 48.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This AP1M1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-227 amino acids from the Central region of human AP1M1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AP1M1抗体的3篇参考文献示例(注：文献信息为示例性概括，实际引用需核实具体数据库)：
1. **文献名称**：*"AP1M1 controls trans-Golgi network protein sorting and cell polarity"*
**作者**：Meyer et al.
**摘要**：研究利用AP1M1特异性抗体，通过免疫荧光和免疫印迹技术，揭示了AP1M1在维持高尔基体-质膜蛋白运输及上皮细胞极性中的关键作用。
2. **文献名称**：*"AP1M1 deficiency disrupts synaptic vesicle recycling in neurons"*
**作者**：Li et al.
**摘要**：通过AP1M1抗体标记，发现AP1M1缺失导致神经元突触小泡分选异常，表明其在神经递质运输中的必要性。
3. **文献名称**：*"AP1M1 expression correlates with colorectal cancer progression"*
**作者**：Zhang et al.
**摘要**：采用AP1M1抗体进行免疫组化分析，发现AP1M1在结直肠癌中表达下调，且与患者生存率降低显著相关。
建议通过 **PubMed** 或 **Google Scholar** 检索真实文献，关键词：AP1M1 antibody、AP1M1 function、AP1M1 disease。
The AP1M1 antibody targets the μ1 subunit of the Adaptor Protein Complex 1 (AP-1), a heterotetrameric complex involved in clathrin-mediated intracellular trafficking. AP-1 facilitates the sorting of cargo proteins between the trans-Golgi network (TGN) and endosomes, playing a critical role in maintaining cellular homeostasis. The μ1 subunit (encoded by the *AP1M1* gene) is essential for AP-1 assembly and its interaction with tyrosine-based sorting motifs on cargo molecules.
Research on AP1M1 has linked its dysfunction to neurodevelopmental disorders and cancer. For example, mutations in *AP1M1* are associated with MEDNIK syndrome, a rare autosomal recessive disorder characterized by intellectual disability, dermatological abnormalities, and metabolic defects. AP1M1 is also implicated in tumor progression due to its role in regulating cell surface receptor internalization and signaling pathways.
The AP1M1 antibody is widely used in studies exploring intracellular transport mechanisms, protein localization, and disease pathogenesis. Common applications include Western blotting, immunofluorescence, and immunoprecipitation to assess AP-1 complex formation, subcellular distribution, or expression levels in various tissues. Commercially available antibodies are typically raised in rabbits or mice, with specificity validated through knockout controls or siRNA-mediated silencing. Its utility extends to both basic research and clinical investigations, particularly in understanding trafficking-related pathologies.
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